Methods and apparatus to insert prefetch instructions based on garbage collector analysis and compiler analysis are disclosed. In an example method, one or more batches of samples associated with cache misses from a performance monitoring unit in a processor system are received. One or more samples from the one or more batches of samples based on delinquent information are selected. A performance impact indicator associated with the one or more samples is generated. Based on the performance indicator, at least one of a garbage collector analysis and a compiler analysis is initiated to identify one or more delinquent paths. Based on the at least one of the garbage collector analysis and the compiler analysis, one or more prefetch points to insert prefetch instructions are identified.