发明授权
- 专利标题: Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding same, and methods of use thereof
- 专利标题(中): 涉及信号转导的TNF超家族的蛋白质,其编码的核酸及其使用方法
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申请号: US11032797申请日: 2005-01-11
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公开(公告)号: US07393927B2公开(公告)日: 2008-07-01
- 发明人: Yongwon Choi , Brian Wong , Regis Josien , Ralph Steinman
- 申请人: Yongwon Choi , Brian Wong , Regis Josien , Ralph Steinman
- 申请人地址: US NY New York
- 专利权人: The Rockefeller University
- 当前专利权人: The Rockefeller University
- 当前专利权人地址: US NY New York
- 代理机构: Drinker Biddle & Reath LLP
- 主分类号: C07K14/525
- IPC分类号: C07K14/525 ; A61K38/19 ; C12P21/02 ; C07H21/04 ; C12N1/20 ; C12N5/02
摘要:
A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo. Preferably, the method of the present invention results in increasing immune response towards the antigen in the animal.