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    Protein Belonging to the TNF Superfamily Involved in Signal Transduction, Nucleic Acids Encoding Same and Methods of Use Thereof
    1.
    发明申请
    Protein Belonging to the TNF Superfamily Involved in Signal Transduction, Nucleic Acids Encoding Same and Methods of Use Thereof 有权
    属于涉及信号转导的TNF超家族的蛋白质，编码相同的核酸及其使用方法

    公开(公告)号：US20120135496A1

    公开(公告)日：2012-05-31

    申请号：US12840967

    申请日：2010-07-21

    申请人： Yongwon Choi ,  Brian Wong ,  Regis Josien ,  Ralph Steinman

    发明人： Yongwon Choi ,  Brian Wong ,  Regis Josien ,  Ralph Steinman

    IPC分类号： C07K16/18 ,  C12N9/96 ,  C07K16/46

    CPC分类号： C07K16/2875 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/525 ,  C07K14/70575 ,  C07K2317/76 ,  C07K2319/30 ,  C12N15/1096

    摘要： A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo. Preferably, the method of the present invention results in increasing immune response towards the antigen in the animal.

    摘要翻译： 公开了调节动物免疫应答的方法。 这种方法将来自动物的未成熟树突状细胞与抗原离体相互作用，使得未成熟树突细胞在其表面上存在抗原，诱导未成熟树突状细胞离体成熟，并使成熟树突状细胞离体与调节剂接触 包括TRANCE，其保守变体，其片段，其类似物或衍生物，或包含TRANCE的氨基酸序列，其保守变体或其片段的融合蛋白。 离体调节剂离体接触后，将成熟树突状细胞导入动物体内。 因此，动物中针对抗原的免疫反应相对于动物中针对抗原的免疫应答进行调节，其中树突细胞离体不与抗原相互作用，并且不离体接触调节剂。 优选地，本发明的方法导致对动物中抗原的免疫应答增加。

    Protein belonging to the TNF superfamily involved in signal transduction and methods of use thereof
    2.
    发明授权
    Protein belonging to the TNF superfamily involved in signal transduction and methods of use thereof 有权
    参与信号转导的TNF超家族的蛋白质及其使用方法

    公开(公告)号：US07622442B2

    公开(公告)日：2009-11-24

    申请号：US11241106

    申请日：2005-09-30

    申请人： Yongwon Choi ,  Brian Wong ,  Regis Josien ,  Ralph Steinman

    发明人： Yongwon Choi ,  Brian Wong ,  Regis Josien ,  Ralph Steinman

    IPC分类号： A61K38/17 ,  A61K38/19 ,  C07K14/00 ,  C07K14/52

    CPC分类号： C07K16/2875 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/525 ,  C07K14/70575 ,  C07K2317/76 ,  C07K2319/30 ,  C12N15/1096

    摘要： A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo. Preferably, the method of the present invention results in increasing immune response towards the antigen in the animal.

    摘要翻译： 公开了调节动物免疫应答的方法。 这种方法将来自动物的未成熟树突状细胞与抗原离体相互作用，使得未成熟树突状细胞在其表面上存在抗原，诱导未成熟树突状细胞离体成熟，并使成熟树突状细胞离体与调节剂接触 包括TRANCE，其保守变体，其片段，其类似物或衍生物，或包含TRANCE的氨基酸序列，其保守变体或其片段的融合蛋白。 离体调节剂离体接触后，将成熟树突状细胞导入动物体内。 因此，动物中针对抗原的免疫反应相对于动物中针对抗原的免疫应答进行调节，其中树突细胞离体不与抗原相互作用，并且不离体接触调节剂。 优选地，本发明的方法导致对动物中抗原的免疫应答增加。

    Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding same, and methods of use thereof
    3.
    发明申请
    Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding same, and methods of use thereof 有权
    涉及信号转导的TNF超家族的蛋白质，其编码的核酸及其使用方法

    公开(公告)号：US20060159654A1

    公开(公告)日：2006-07-20

    申请号：US11241106

    申请日：2005-09-30

    申请人： Yongwon Choi ,  Brian Wong ,  Regis Josien ,  Ralph Steinman

    发明人： Yongwon Choi ,  Brian Wong ,  Regis Josien ,  Ralph Steinman

    IPC分类号： A61K38/19 ,  C07K14/525 ,  C12Q1/68 ,  C07H21/04 ,  C12P21/02 ,  C07K16/24

    CPC分类号： C07K16/2875 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/525 ,  C07K14/70575 ,  C07K2317/76 ,  C07K2319/30 ,  C12N15/1096

    摘要： A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo. Preferably, the method of the present invention results in increasing immune response towards the antigen in the animal.

    摘要翻译： 公开了调节动物免疫应答的方法。 这种方法将来自动物的未成熟树突状细胞与抗原离体相互作用，使得未成熟树突状细胞在其表面上存在抗原，诱导未成熟树突状细胞离体成熟，并使成熟树突状细胞离体与调节剂接触 包括TRANCE，其保守变体，其片段，其类似物或衍生物，或包含TRANCE的氨基酸序列，其保守变体或其片段的融合蛋白。 离体调节剂离体接触后，将成熟树突状细胞导入动物体内。 因此，动物中针对抗原的免疫反应相对于动物中针对抗原的免疫应答进行调节，其中树突细胞离体不与抗原相互作用，并且不离体接触调节剂。 优选地，本发明的方法导致对动物中抗原的免疫应答增加。

    Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding same, and methods of use thereof
    6.
    发明授权
    Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding same, and methods of use thereof 有权
    涉及信号转导的TNF超家族的蛋白质，其编码的核酸及其使用方法

    公开(公告)号：US07393927B2

    公开(公告)日：2008-07-01

    申请号：US11032797

    申请日：2005-01-11

    申请人： Yongwon Choi ,  Brian Wong ,  Regis Josien ,  Ralph Steinman

    发明人： Yongwon Choi ,  Brian Wong ,  Regis Josien ,  Ralph Steinman

    IPC分类号： C07K14/525 ,  A61K38/19 ,  C12P21/02 ,  C07H21/04 ,  C12N1/20 ,  C12N5/02

    CPC分类号： C07K16/2875 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/525 ,  C07K14/70575 ,  C07K2317/76 ,  C07K2319/30 ,  C12N15/1096

    摘要： A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo. Preferably, the method of the present invention results in increasing immune response towards the antigen in the animal.

    摘要翻译： 公开了调节动物免疫应答的方法。 这种方法将来自动物的未成熟树突状细胞与抗原离体相互作用，使得未成熟树突细胞在其表面上存在抗原，诱导未成熟树突状细胞离体成熟，并使成熟树突状细胞离体与调节剂接触 包括TRANCE，其保守变体，其片段，其类似物或衍生物，或包含TRANCE的氨基酸序列，其保守变体或其片段的融合蛋白。 离体调节剂离体接触后，将成熟树突状细胞导入动物体内。 因此，动物中针对抗原的免疫反应相对于动物中针对抗原的免疫应答进行调节，其中树突细胞离体不与抗原相互作用，并且不离体接触调节剂。 优选地，本发明的方法导致对动物中抗原的免疫应答增加。

    Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding same and methods of use thereof
    9.
    发明授权
    Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding same and methods of use thereof 有权
    涉及信号转导的TNF超家族的蛋白质，其编码的核酸及其使用方法

    公开(公告)号：US08637020B2

    公开(公告)日：2014-01-28

    申请号：US13586514

    申请日：2012-08-15

    申请人： Yongwon Choi ,  Brian Wong

    发明人： Yongwon Choi ,  Brian Wong

    IPC分类号： A61K39/395

    CPC分类号： C07K16/2875 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/525 ,  C07K14/70575 ,  C07K2317/76 ,  C07K2319/30 ,  C12N15/1096

    摘要： A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo. Preferably, the method of the present invention results in increasing immune response towards the antigen in the animal.

    摘要翻译： 公开了调节动物免疫应答的方法。 这种方法将来自动物的未成熟树突状细胞与抗原离体相互作用，使得未成熟树突状细胞在其表面上存在抗原，诱导未成熟树突状细胞离体成熟，并使成熟树突状细胞离体与调节剂接触 包括TRANCE，其保守变体，其片段，其类似物或衍生物，或包含TRANCE的氨基酸序列，其保守变体或其片段的融合蛋白。 离体调节剂离体接触后，将成熟树突状细胞导入动物体内。 因此，动物中针对抗原的免疫反应相对于动物中针对抗原的免疫应答进行调节，其中树突细胞离体不与抗原相互作用，并且不离体接触调节剂。 优选地，本发明的方法导致对动物中抗原的免疫应答增加。

    Trance activated signal transduction pathways in osteoclasts
    10.
    发明授权
    Trance activated signal transduction pathways in osteoclasts 有权
    恍惚激活信号转导通路在破骨细胞

    公开(公告)号：US06492124B1

    公开(公告)日：2002-12-10

    申请号：US09330867

    申请日：1999-06-11

    申请人： Brian Wong ,  Daniel Besser ,  Yongwon Choi

    发明人： Brian Wong ,  Daniel Besser ,  Yongwon Choi

    IPC分类号： G01N33567

    CPC分类号： C07K14/70575 ,  G01N33/6863 ,  G01N33/6887 ,  G01N2500/00

    摘要： The present invention relates to methods and compositions for modulating activity of a TRANCE receptor, including the modulation of TRANCE signaling activity. In particular, the invention provides screening methods by which novel modulators of TRANCE signaling may be identified, including TRANCE inhibitors, agonists and antagonists. The invention also relates to the identification of one or more specific pathways for osteoclast surivival, and the manipulation of this pathway (e.g., using a TRANCE modulator of the invention). Such manipulation may provide strategies for treating osteoclast-related diseases such as osteoporosis and osteopetrosis.

    摘要翻译： 本发明涉及用于调节TRANCE受体活性的方法和组合物，包括TRANCE信号传导活性的调节。 特别地，本发明提供了可以鉴定TRANCE信号传导的新型调节剂的筛选方法，包括TRANCE抑制剂，激动剂和拮抗剂。 本发明还涉及鉴定破骨细胞周转的一个或多个特异性途径，以及对该途径的操作（例如，使用本发明的TRANCE调节剂）。 这种操作可以提供治疗破骨细胞相关疾病如骨质疏松症和骨硬化症的策略。