发明授权
- 专利标题： Method for identifying and killing cancer cells
- 专利标题（中）： 识别和杀死癌细胞的方法
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申请号： US10208243申请日： 2002-07-30
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公开(公告)号： US07402307B2公开(公告)日： 2008-07-22
- 发明人: Federico C. A. Gaeta
- 申请人： Federico C. A. Gaeta
- 申请人地址： US CA Menlo Park
- 专利权人： Geron Corporation
- 当前专利权人： Geron Corporation
- 当前专利权人地址： US CA Menlo Park
- 代理商 Leslie A. Mooi; David J. Earp
- 主分类号： A01N63/00
- IPC分类号： A01N63/00 ; C12N5/06
摘要：
The invention provides a method for activating a T lymphocyte by contacting the T lymphocyte with a dendritic cell (DC) that presents a telomerase reverse transcriptase (TRT) peptide in the context of an MHC class I or MHC class II molecule. The DC may be pulsed with a TRT polypeptide or may comprise a recombinant polynucleotide encoding a TRT such as hTRT. The invention also provides DCs comprising a recombinant TRT polynucleotide. The methods and compositions of the invention are used in prevention and treatment of cancers and other cell proliferation diseases or conditions.
公开/授权文献
- US20030044394A1 Method for identifying and killing cancer cells 公开/授权日：2003-03-06
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