发明授权
- 专利标题： Method for monitoring collagen type II degradation in cartilage
- 专利标题（中）： 监测软骨II型胶原蛋白降解的方法
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申请号： US10507498申请日： 2003-03-12
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公开(公告)号： US07410770B2公开(公告)日： 2008-08-12
- 发明人: Jean-Yves Reginster , Michelle Deberg , Yves Henrotin , Stephan Christgau
- 申请人： Jean-Yves Reginster , Michelle Deberg , Yves Henrotin , Stephan Christgau
- 申请人地址： BE Liege
- 专利权人： Universite De Liege
- 当前专利权人： Universite De Liege
- 当前专利权人地址： BE Liege
- 代理机构： Jacobson Holman PLLC
- 优先权： DK200200380 20020313
- 国际申请： PCT/EP03/02561 WO 20030312
- 国际公布： WO03/076947 WO 20030918
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; G01N33/68 ; A61K38/39
摘要：
A method for improving the diagnostic assessment of cartilage degenerative processes, and to provide means of monitoring the effects of therapeutical measures taken towards arthritic diseases in most mammals utilizes an immunoassay to detect fragments of collagen type II resulting from collagenase activity comprising an antibody directed against an epitope comprised in the amino acid sequence HRGYPGLDG, located in the helical region of collagen type II.
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