DETECTION OF SPECIFIC NITRATED MARKERS
    2.
    发明申请
    DETECTION OF SPECIFIC NITRATED MARKERS 有权
    检测特异性标记

    公开(公告)号:US20120010389A1

    公开(公告)日:2012-01-12

    申请号:US13221014

    申请日:2011-08-30

    IPC分类号: C07K16/00

    摘要: Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, and to provide means of monitoring the effects of therapeutical measures taken towards such diseases. The invention enables the detection of disease specific catabolic markers related to oxidative NO-modifications, utilizing an immunoassay comprising antibodies directed against nitrated and non-nitrated epitopes characteristic of a specific protein.

    摘要翻译: 描述了用于改善发生氧化性NO-修饰的疾病的诊断可能性的方法,例如炎性病症,癌症,帕金森病或阿尔茨海默病,并提供监测对这些疾病采取的治疗措施的效果的方法。 本发明能够利用包含针对特异性蛋白特征性的硝化和非硝化表位的抗体的免疫测定来检测与氧化性NO修饰相关的疾病特异性分解代谢标志物。

    Detection of specific nitrated markers
    6.
    发明授权
    Detection of specific nitrated markers 有权
    检测特异性硝化标记物

    公开(公告)号:US08329874B2

    公开(公告)日:2012-12-11

    申请号:US13221014

    申请日:2011-08-30

    IPC分类号: C07K16/18 C07K16/00

    摘要: Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, and to provide means of monitoring the effects of therapeutical measures taken towards such diseases. The invention enables the detection of disease specific catabolic markers related to oxidative NO-modifications, utilizing an immunoassay comprising antibodies directed against nitrated and non-nitrated epitopes characteristic of a specific protein.

    摘要翻译: 描述了用于改善发生氧化性NO-修饰的疾病的诊断可能性的方法,例如炎性病症,癌症,帕金森病或阿尔茨海默病,并提供监测对这些疾病采取的治疗措施的效果的方法。 本发明能够利用包含针对特异性蛋白特征性的硝化和非硝化表位的抗体的免疫测定来检测与氧化性NO修饰相关的疾病特异性分解代谢标志物。