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公开(公告)号：US07728112B2
公开(公告)日：2010-06-01
申请号：US12222352
申请日：2008-08-07
IPC分类号： C07K16/18 , G01N33/53 , G01N33/543
CPC分类号： C07K16/18 , G01N33/6887 , G01N2333/78 , Y10S530/84
摘要： A method for improving the diagnostic assessment of cartilage degenerative processes, and to provide means of monitoring the effects of therapeutical measures taken towards arthritic diseases in most mammals utilizes an immunoassay to detect fragments of collagen type II resulting from collagenase activity comprising an antibody directed against an epitope comprised in the amino acid sequence HRGYPGLDG (SEQ ID NO:1), located in the helical region of collagen type II.
摘要翻译： 用于改善软骨退化过程的诊断评估的方法以及提供监测在大多数哺乳动物中对关节炎疾病采取的治疗措施的作用的方法利用免疫测定来检测由胶原酶活性产生的II型胶原蛋白的片段，其包含针对 位于II型胶原螺旋区的氨基酸序列HRGYPGLDG（SEQ ID NO：1）中的表位。
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公开(公告)号：US07393649B2
公开(公告)日：2008-07-01
申请号：US10507479
申请日：2003-03-12
CPC分类号： G01N33/6803 , C07K16/18 , G01N33/564 , G01N33/6887 , G01N33/6893 , G01N33/6896 , Y10S530/84 , Y10T436/173076
摘要： Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, and to provide means of monitoring the effects of therapeutical measures taken towards such diseases. The invention enables the detection of disease specific catabolic markers related to oxidative NO-modifications, utilizing an immunoassay comprising antibodies directed against nitrated and non-nitrated epitopes characteristic of a specific protein.
摘要翻译： 描述了用于改善发生氧化性NO-修饰的疾病的诊断可能性的方法，例如炎性病症，癌症，帕金森病或阿尔茨海默病，并提供监测对这些疾病采取的治疗措施的效果的方法。 本发明能够利用包含针对特异性蛋白特征性的硝化和非硝化表位的抗体的免疫测定来检测与氧化性NO修饰相关的疾病特异性分解代谢标志物。
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公开(公告)号：US20120010389A1
公开(公告)日：2012-01-12
申请号：US13221014
申请日：2011-08-30
IPC分类号： C07K16/00
CPC分类号： G01N33/6803 , C07K16/18 , G01N33/564 , G01N33/6887 , G01N33/6893 , G01N33/6896 , Y10S530/84 , Y10T436/173076
摘要： Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, and to provide means of monitoring the effects of therapeutical measures taken towards such diseases. The invention enables the detection of disease specific catabolic markers related to oxidative NO-modifications, utilizing an immunoassay comprising antibodies directed against nitrated and non-nitrated epitopes characteristic of a specific protein.
摘要翻译： 描述了用于改善发生氧化性NO-修饰的疾病的诊断可能性的方法，例如炎性病症，癌症，帕金森病或阿尔茨海默病，并提供监测对这些疾病采取的治疗措施的效果的方法。 本发明能够利用包含针对特异性蛋白特征性的硝化和非硝化表位的抗体的免疫测定来检测与氧化性NO修饰相关的疾病特异性分解代谢标志物。
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4.发明申请BIOMARKER FOR OSTEOARTHRITIS AND/OR OTHER AGEING-RELATED DISEASES, AND USE THEREOF 有权OSTEOARTHRITIS和/或其他与老年相关的疾病的生物标记及其使用公开(公告)号：US20110159514A1
公开(公告)日：2011-06-30
申请号：US12737051
申请日：2009-02-27
申请人： Yves Henrotin , Myriam Gharbi , Michelle Deberg , Edwin De Pauw
发明人： Yves Henrotin , Myriam Gharbi , Michelle Deberg , Edwin De Pauw
IPC分类号： G01N33/68 , C07K16/18 , C07K14/00 , C12N9/00 , C07K14/47 , C07H21/00 , C12N15/63 , C12N5/10 , C12N1/00
CPC分类号： G01N33/564 , G01N33/6887 , G01N2333/78 , G01N2800/105
摘要： The invention relates to the identification of a biomarker whose abundance in biological sample is changed in subjects with osteoarthritis and/or other ageing-related diseases. The biomarker has applications in the diagnosis of osteoarthritis and/or other ageing-related diseases, in determining the prognosis for an individual diagnosed with osteoarthritis and/or other ageing-related diseases, and in monitoring the efficacy of treatment for osteoarthritis and/or other ageing-related diseases.
摘要翻译： 本发明涉及生物标志物的鉴定，其生物样品的丰度在具有骨关节炎和/或其它老化相关疾病的受试者中改变。 该生物标志物在诊断骨关节炎和/或其他与衰老有关的疾病方面有应用，用于确定被诊断为骨关节炎和/或其他与老化有关的疾病的个体的预后，以及监测治疗骨关节炎和/或其他 老化相关疾病
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公开(公告)号：US20050176081A1
公开(公告)日：2005-08-11
申请号：US10507479
申请日：2003-03-12
IPC分类号： C07K16/18 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/564 , G01N33/68
CPC分类号： G01N33/6803 , C07K16/18 , G01N33/564 , G01N33/6887 , G01N33/6893 , G01N33/6896 , Y10S530/84 , Y10T436/173076
摘要： Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, and to provide means of monitoring the effects of therapeutical measures taken towards such diseases. The invention enables the detection of disease specific catabolic markers related to oxidative NO-modifications, utilizing an immunoassay comprising antibodies directed against nitrated and non-nitrated epitopes characteristic of a specific protein.
摘要翻译： 描述了用于改善发生氧化性NO-修饰的疾病的诊断可能性的方法，例如炎性病症，癌症，帕金森病或阿尔茨海默病，并提供监测对这些疾病采取的治疗措施的效果的方法。 本发明能够利用包含针对特异性蛋白特征性的硝化和非硝化表位的抗体的免疫测定来检测与氧化性NO修饰相关的疾病特异性分解代谢标志物。
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公开(公告)号：US08329874B2
公开(公告)日：2012-12-11
申请号：US13221014
申请日：2011-08-30
CPC分类号： G01N33/6803 , C07K16/18 , G01N33/564 , G01N33/6887 , G01N33/6893 , G01N33/6896 , Y10S530/84 , Y10T436/173076
摘要： Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, and to provide means of monitoring the effects of therapeutical measures taken towards such diseases. The invention enables the detection of disease specific catabolic markers related to oxidative NO-modifications, utilizing an immunoassay comprising antibodies directed against nitrated and non-nitrated epitopes characteristic of a specific protein.
摘要翻译： 描述了用于改善发生氧化性NO-修饰的疾病的诊断可能性的方法，例如炎性病症，癌症，帕金森病或阿尔茨海默病，并提供监测对这些疾病采取的治疗措施的效果的方法。 本发明能够利用包含针对特异性蛋白特征性的硝化和非硝化表位的抗体的免疫测定来检测与氧化性NO修饰相关的疾病特异性分解代谢标志物。
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公开(公告)号：US07410770B2
公开(公告)日：2008-08-12
申请号：US10507498
申请日：2003-03-12
CPC分类号： C07K16/18 , G01N33/6887 , G01N2333/78 , Y10S530/84
摘要： A method for improving the diagnostic assessment of cartilage degenerative processes, and to provide means of monitoring the effects of therapeutical measures taken towards arthritic diseases in most mammals utilizes an immunoassay to detect fragments of collagen type II resulting from collagenase activity comprising an antibody directed against an epitope comprised in the amino acid sequence HRGYPGLDG, located in the helical region of collagen type II.
摘要翻译： 用于改善软骨退化过程的诊断评估的方法以及提供监测在大多数哺乳动物中对关节炎疾病采取的治疗措施的作用的方法利用免疫测定来检测由胶原酶活性产生的II型胶原蛋白的片段，其包含针对 位于II型胶原螺旋区的氨基酸序列HRGYPGLDG中的表位。
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公开(公告)号：US20110223684A1
公开(公告)日：2011-09-15
申请号：US13010357
申请日：2011-01-20
IPC分类号： G01N33/566 , C12N5/071 , C07K16/44
CPC分类号： G01N33/6803 , C07K16/18 , G01N33/564 , G01N33/6887 , G01N33/6893 , G01N33/6896 , Y10S530/84 , Y10T436/173076
摘要： Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, and to provide means of monitoring the effects of therapeutical measures taken towards such diseases. The invention enables the detection of disease specific catabolic markers related to oxidative NO-modifications, utilizing an immunoassay comprising antibodies directed against nitrated and non-nitrated epitopes characteristic of a specific protein.
摘要翻译： 描述了用于改善发生氧化性NO-修饰的疾病的诊断可能性的方法，例如炎性病症，癌症，帕金森病或阿尔茨海默病，并提供监测对这些疾病采取的治疗措施的效果的方法。 本发明能够利用包含针对特异性蛋白特征性的硝化和非硝化表位的抗体的免疫测定来检测与氧化性NO修饰相关的疾病特异性分解代谢标志物。
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公开(公告)号：US20090203040A1
公开(公告)日：2009-08-13
申请号：US12216063
申请日：2008-06-27
IPC分类号： G01N33/567 , G01N33/574 , C07K16/40
CPC分类号： G01N33/6803 , C07K16/18 , G01N33/564 , G01N33/6887 , G01N33/6893 , G01N33/6896 , Y10S530/84 , Y10T436/173076
摘要： Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, and to provide means of monitoring the effects of therapeutical measures taken towards such diseases. The invention enables the detection of disease specific catabolic markers related to oxidative NO-modifications, utilizing an immunoassay comprising antibodies directed against nitrated and non-nitrated epitopes characteristic of a specific protein.
摘要翻译： 描述了用于改善发生氧化性NO-修饰的疾病的诊断可能性的方法，例如炎性病症，癌症，帕金森病或阿尔茨海默病，并提供监测对这些疾病采取的治疗措施的效果的方法。 本发明能够利用包含针对特异性蛋白特征性的硝化和非硝化表位的抗体的免疫测定来检测与氧化性NO修饰相关的疾病特异性分解代谢标志物。
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公开(公告)号：US20090042220A1
公开(公告)日：2009-02-12
申请号：US12222352
申请日：2008-08-07
IPC分类号： G01N33/567 , C07K7/06 , C07K16/00 , C12N5/06
CPC分类号： C07K16/18 , G01N33/6887 , G01N2333/78 , Y10S530/84
摘要： A method for improving the diagnostic assessment of cartilage degenerative processes, and to provide means of monitoring the effects of therapeutical measures taken towards arthritic diseases in most mammals utilizes an immunoassay to detect fragments of collagen type II resulting from collagenase activity comprising an antibody directed against an epitope comprised in the amino acid sequence HRGYPGLDG (SEQ ID NO:1), located in the helical region of collagen type II.
摘要翻译： 用于改善软骨退化过程的诊断评估的方法以及提供监测在大多数哺乳动物中对关节炎疾病采取的治疗措施的作用的方法利用免疫测定来检测由胶原酶活性产生的II型胶原蛋白的片段，其包含针对 位于II型胶原螺旋区的氨基酸序列HRGYPGLDG（SEQ ID NO：1）中的表位。
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