发明授权
- 专利标题： Substrates and screening methods for transport proteins
- 专利标题（中）： 转运蛋白的底物和筛选方法
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申请号： US09661927申请日： 2000-09-14
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公开(公告)号： US07413536B1公开(公告)日： 2008-08-19
- 发明人: William J. Dower , Mark A. Gallop , Ronald W. Barrett , Kenneth C. Cundy , Tania Chernov-Rogan
- 申请人： William J. Dower , Mark A. Gallop , Ronald W. Barrett , Kenneth C. Cundy , Tania Chernov-Rogan
- 申请人地址： US CA Santa Clara
- 专利权人： XenoPort, Inc.
- 当前专利权人： XenoPort, Inc.
- 当前专利权人地址： US CA Santa Clara
- 代理机构： Townsend and Townsend and Crew LLP
- 主分类号： C40B30/04
- IPC分类号： C40B30/04
摘要：
A variety of methods for assaying libraries of test compounds as ligands and/or substrates of transport proteins, including both carrier-type and receptor-type transport proteins, are provided. Both in vitro and in vivo screening methods are disclosed. Also provided are methods for screening DNA libraries to identify members that encode transport proteins. Pharmaceutical compositions including compounds identified via the screening methods are also provided.
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