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    Treating urinary incontinence using prodrugs of GABA analogs
    1.
    发明授权
    Treating urinary incontinence using prodrugs of GABA analogs 失效
    使用GABA类似物的前药治疗尿失禁

    公开(公告)号：US07700652B2

    公开(公告)日：2010-04-20

    申请号：US10940884

    申请日：2004-09-13

    申请人： Ronald W. Barrett

    发明人： Ronald W. Barrett

    IPC分类号： A61K31/195 ,  A61K31/19

    CPC分类号： A61K31/47 ,  A61K31/195

    摘要： Disclosed herein are methods of using prodrugs of GABA analogs and pharmaceutical compositions thereof to treat and/or prevent urinary incontinence in humans, and pharmaceutical compositions of prodrugs of GABA analogs useful in treating and/or preventing urinary incontinence.

    摘要翻译： 本文公开了使用GABA类似物的前药和其药物组合物治疗和/或预防人尿失禁的方法，以及可用于治疗和/或预防尿失禁的GABA类似物前药药物组合物。

    COMPOUNDS DISPLAYED ON REPLICABLE GENETIC PACKAGES AND METHODS OF USING SAME
    2.
    发明申请
    COMPOUNDS DISPLAYED ON REPLICABLE GENETIC PACKAGES AND METHODS OF USING SAME 审中-公开
    在可替代遗传包装上显示的化合物及其使用方法

    公开(公告)号：US20090233808A1

    公开(公告)日：2009-09-17

    申请号：US12395311

    申请日：2009-02-27

    申请人： Ronald W. Barrett ,  William J. Dower ,  Mark Gallop ,  Thomas F. Woiwode ,  Steven E. Cwirla

    发明人： Ronald W. Barrett ,  William J. Dower ,  Mark Gallop ,  Thomas F. Woiwode ,  Steven E. Cwirla

    IPC分类号： C40B30/04

    CPC分类号： C12N15/1037

    摘要： Replicable genetic packages and collections thereof that display various compounds are provided. In some instances, the replicable genetic packages include nucleic acid tags that serve to record a characteristic of the compound or compounds that are attached to the replicable genetic package. The invention further provides a number of different methods for using the replicable genetic packages to screen a library of compounds for a desired biological activity.

    摘要翻译： 提供显示各种化合物的可复制的遗传包装及其集合。 在一些情况下，可复制遗传包装包括用于记录附着于可复制遗传包装的化合物或化合物的特征的核酸标签。 本发明还提供了许多不同的使用可复制遗传包装以筛选化合物文库以获得所需生物学活性的方法。

    Peptides and compounds that bind to the IL-1 receptor
    6.
    发明授权
    Peptides and compounds that bind to the IL-1 receptor 失效

    公开(公告)号：US5786331A

    公开(公告)日：1998-07-28

    申请号：US465391

    申请日：1995-06-05

    申请人： Ronald W. Barrett ,  Stephen D. Yanofsky ,  David Baldwin ,  Jeff W. Jacobs ,  Phillipe R. Bovy ,  Ellen M. Leahy ,  Richard S. Pottorf

    发明人： Ronald W. Barrett ,  Stephen D. Yanofsky ,  David Baldwin ,  Jeff W. Jacobs ,  Phillipe R. Bovy ,  Ellen M. Leahy ,  Richard S. Pottorf

    IPC分类号： A61K38/00 ,  C07K14/545 ,  A61K38/08 ,  C07K7/04

    CPC分类号： C07K14/545 ,  A61K38/00

    摘要： Peptides that bind to the interleukin-1 type I receptor (IL-1RtI) can be used to assay the amount of IL-1R, or an IL-1R agonist or antagonist, in a sample and comprise a sequence of amino acids selected from the group consisting of (1) WXXXGZ.sub.1 W where Z.sub.1 is L, I, A, or Q; (2) XXQZ.sub.5 YZ.sub.6 XX where Z.sub.5 is P or Aze where Aze is azetidine; and Z.sub.6 is S, A, V, or L; and (3) Z.sub.23 NZ.sub.24 SZ.sub.25 Z.sub.26 Z.sub.27 Z.sub.28 Z.sub.29 Z.sub.30 L where Z.sub.23 is D or Y; Z.sub.24 is D or S; Z.sub.25 is S or W; Z.sub.26 is S or Y; Z.sub.27 is D or V; Z.sub.28 is S or W; Z.sub.29 is F or L; and Z.sub.30 is D or L; and where each amino acid is indicated by standard one letter abbreviation; and each X can be selected from any one of the 20 genetically coded L-amino acids or the stereoisomeric D-amino acids. Also provided are peptides which bind to the IL-1RtI, which are 11 to 40 amino acids in length, which comprise the core sequence of amino acids: Z.sub.31 XWZ.sub.32 Z.sub.33 Z.sub.34 Z.sub.35 Z.sub.36 QZ.sub.37 Z.sub.38 where each letter represents the standard one letter abbreviation for an amino acid or an analog thereof; X is selected from the group of natural or unnatural amino acids; Z.sub.37 is a natural or unnatural cyclic amino acid; Z.sub.31 is selected from phenylalanine and acetylated phenylalanine; Z.sub.32 is a natural or unnatural amino acid; Z.sub.33 is selected from proline and pipecolic acid; Z.sub.34 is selected from glycine, d-alanine, d-valine, sarcosine and aminoisobutyric acid; Z.sub.35 is a natural or unnatural amino acid and Z.sub.36 is selected from tyrosine, phosphotyrosine, phenylalanine and tryptophan; and Z.sub.38 is selected from tyrosinamide and substituted tyrosinamide.

    Peptides that bind IL-2 receptors
    8.
    发明授权
    Peptides that bind IL-2 receptors 失效
    结合IL-2受体的肽

    公开(公告)号：US5635597A

    公开(公告)日：1997-06-03

    申请号：US250789

    申请日：1994-05-27

    申请人： Ronald W. Barrett ,  Tania Chernov-Rogan ,  Ann M. Davis

    发明人： Ronald W. Barrett ,  Tania Chernov-Rogan ,  Ann M. Davis

    IPC分类号： A61K38/00 ,  C07K7/08 ,  C07K14/715

    CPC分类号： C07K7/08 ,  C07K14/7155 ,  A61K38/00

    摘要： Peptides that bind to the Interleukin-2 (IL-2) receptor subunits IL-2R.alpha., IL-2R.beta. and IL-2R.gamma., and inhibit the binding of IL-2 to these important receptors, are described. The invention also includes methods for treating diseases related to the activation of these receptors, as well as the receptors for IL-4, -7 and -13. In addition, the present invention also includes methods for assaying for the presence of these receptors on cell surfaces.

    摘要翻译： 描述了结合白细胞介素-2（IL-2）受体亚基IL-2Rα，IL-2Rβ和IL-2Rγ并抑制IL-2与这些重要受体结合的肽。 本发明还包括治疗与这些受体的活化有关的疾病以及用于IL-4，-7和-13的受体的方法。 此外，本发明还包括用于测定细胞表面上这些受体的存在的方法。