发明授权
US07414119B2 Aldolases, nucleic acids encoding them and methods for making and using them
失效
醛缩酶，编码它们的核酸和制备和使用它们的方法
- 专利标题： Aldolases, nucleic acids encoding them and methods for making and using them
- 专利标题（中）： 醛缩酶，编码它们的核酸和制备和使用它们的方法
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申请号： US10472157申请日： 2003-08-19
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公开(公告)号： US07414119B2公开(公告)日： 2008-08-19
- 发明人: William Greenberg , Mark J. Burk , Alexander Varvak , Kelvin Wong
- 申请人： William Greenberg , Mark J. Burk , Alexander Varvak , Kelvin Wong
- 申请人地址： US CA San Diego
- 专利权人： Verenium Corporation
- 当前专利权人： Verenium Corporation
- 当前专利权人地址： US CA San Diego
- 代理机构： Morrison & Foerster LLP
- 国际申请： PCT/US03/27334 WO 20030819
- 国际公布： WO2004/027075 WO 20040401
- 主分类号： C12N15/60
- IPC分类号： C12N15/60 ; C12N15/62 ; C12N15/79 ; C12N9/88 ; C12N17/06
摘要：
The invention provides novel aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains and compositions comprising these side chains, e.g., [R-(R*,R*)]-2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid (atorvastatin, LIPITOR™), rosuvastatin (CRESTOR™), fluvastatin (LESCOL™), related compounds and their intermediates.
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