发明授权
- 专利标题： Quinoline derivative and quinazoline derivative inhibiting self-phosphorylation of hepatocytus prolifertor receptor and medicinal composition containing the same
- 专利标题（中）： 喹啉衍生物和喹唑啉衍生物抑制肝细胞增生受体的自身磷酸化和含有它的药物组合物
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申请号： US10480632申请日： 2002-06-21
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公开(公告)号： US07425564B2公开(公告)日： 2008-09-16
- 发明人: Yasunari Fujiwara , Terufumi Senga , Tsuyoshi Nishitoba , Tatsushi Osawa , Atsushi Miwa , Kazuhide Nakamura
- 申请人： Yasunari Fujiwara , Terufumi Senga , Tsuyoshi Nishitoba , Tatsushi Osawa , Atsushi Miwa , Kazuhide Nakamura
- 申请人地址： JP Tokyo-To
- 专利权人： Kirin Beer Kabushiki Kaisha
- 当前专利权人： Kirin Beer Kabushiki Kaisha
- 当前专利权人地址： JP Tokyo-To
- 代理机构： Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
- 优先权： JP2001-190238 20010622
- 国际申请： PCT/JP02/06239 WO 20020621
- 国际公布： WO03/000660 WO 20030301
- 主分类号： A61K31/47
- IPC分类号： A61K31/47
摘要：
An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X=CH or N; Z=O or S; L=O or S; M=CR10R11, wherein R10 and R11=H, alkyl, or alkoxy, NR12 wherein R12=H or alkyl; R1, R2, and R3=H or optionally substituted alkoxy; R4=H; R5-8=H, halogen, alkoxy or the like; and R9=alkyl optionally substituted by —R14, -T-R15, or —NR16R17 wherein T=O, S, or NH; R14=an optionally substituted carbocyclic or heterocyclic ring; and R15-17=alkyl or an optionally substituted carbocyclic or heterocyclic ring, or —NR18R19 wherein R18 and R19=H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.