发明授权
- 专利标题： Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
- 专利标题（中）： 使用环加成生物共轭法固定寡核苷酸的方法
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申请号： US09845742申请日： 2001-05-01
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公开(公告)号： US07427678B2公开(公告)日： 2008-09-23
- 发明人: Wolfgang Pieken , Andreas Wolter , David P. Sebesta , Michael Leuck , Hallie A. Latham-Timmons , John Pilon , Gregory M. Husar
- 申请人： Wolfgang Pieken , Andreas Wolter , David P. Sebesta , Michael Leuck , Hallie A. Latham-Timmons , John Pilon , Gregory M. Husar
- 申请人地址： US MO St. Louis
- 专利权人： Sigma-Aldrich Co.
- 当前专利权人： Sigma-Aldrich Co.
- 当前专利权人地址： US MO St. Louis
- 主分类号： C07H21/00
- IPC分类号： C07H21/00 ; A61K38/00 ; C07K1/00
摘要：
This invention discloses a novel method for immobilizing molecules to a support. Specifically, this invention discloses a method of immobilizing derivatized biomolecules, such as oligonucleotides, using cycloaddition reactions, such as the Diels-Alder reaction. Included in this invention are the novel immobilized biomolecules that can be prepared according to the method of this invention.
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