发明授权
US07429385B2 Intracellular production of hepatitis C E1 and E2 truncated polypeptides
失效
丙型肝炎E1和E2截短多肽的细胞内产生
- 专利标题: Intracellular production of hepatitis C E1 and E2 truncated polypeptides
- 专利标题(中): 丙型肝炎E1和E2截短多肽的细胞内产生
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申请号: US10371040申请日: 2003-02-18
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公开(公告)号: US07429385B2公开(公告)日: 2008-09-30
- 发明人: Michael Houghton , Qui-Lim Choo , Sergio Abrignani , David Chien , Mark Selby , Edward Glazer
- 申请人: Michael Houghton , Qui-Lim Choo , Sergio Abrignani , David Chien , Mark Selby , Edward Glazer
- 申请人地址: US CA Emeryville
- 专利权人: Novartis Vaccines & Diagnostics
- 当前专利权人: Novartis Vaccines & Diagnostics
- 当前专利权人地址: US CA Emeryville
- 代理机构: Robins & Pasternak LLP
- 主分类号: A61K39/00
- IPC分类号: A61K39/00 ; C12N15/00
摘要:
Methods for obtaining recombinantly produced, C-terminally truncated, E1 and E2 polypeptides from cell lysates are disclosed. The intracellularly expressed truncated molecules display improved biological properties as compared to their secreted counterparts.
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