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1.发明授权公开(公告)号：US07429385B2
公开(公告)日：2008-09-30
申请号：US10371040
申请日：2003-02-18
申请人： Michael Houghton , Qui-Lim Choo , Sergio Abrignani , David Chien , Mark Selby , Edward Glazer
发明人： Michael Houghton , Qui-Lim Choo , Sergio Abrignani , David Chien , Mark Selby , Edward Glazer
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , Y10S977/923
摘要： Methods for obtaining recombinantly produced, C-terminally truncated, E1 and E2 polypeptides from cell lysates are disclosed. The intracellularly expressed truncated molecules display improved biological properties as compared to their secreted counterparts.
摘要翻译： 公开了从细胞裂解物中获得重组产生的C-末端截短的E1和E2多肽的方法。 与其分泌的对应物相比，细胞内表达的截短分子显示出改善的生物学特性。
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公开(公告)号：US06521423B1
公开(公告)日：2003-02-18
申请号：US09693596
申请日：2000-10-19
申请人： Michael Houghton , Qui-Lim Choo , Sergio Abrignani , David Chien , Mark Selby , Edward Glazer
发明人： Michael Houghton , Qui-Lim Choo , Sergio Abrignani , David Chien , Mark Selby , Edward Glazer
IPC分类号： C12P2100
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , Y10S977/923
摘要： Methods for obtaining recombinantly produced, C-terminally truncated, E1 and E2 polypeptides from cell lysates are disclosed. The intracellularly expressed truncated molecules display improved biological properties as compared to their secreted counterparts.
摘要翻译： 公开了从细胞裂解物获得重组产生的C-末端截短的E1和E2多肽的方法。 与其分泌的对应物相比，细胞内表达的截短分子显示出改善的生物学特性。
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公开(公告)号：US20070092538A1
公开(公告)日：2007-04-26
申请号：US10557427
申请日：2004-05-21
申请人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes
发明人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/545 , A61K2039/55566 , C07K2319/02 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N33/6854 , G01N2333/18 , G01N2469/20 , Y02A50/394
摘要： Recombinant production of immunogenic West Nile Virus (WNV) proteins is described. These proteins, heterodimers comprising the proteins, fusions thereof, polynucleotides encoding the proteins, and combinations thereof, as well as antibodies produced therefrom, can be used in immunogenic compositions for preventing, treating and diagnosing WNV infection. Also described are highly sensitive ELISA and strip immunoassay methods for detecting the presence of WNV in biological samples.
摘要翻译： 描述了免疫原性西尼罗病毒（WNV）蛋白的重组产生。 包含蛋白质的这些蛋白质，其融合物，编码蛋白质的多核苷酸及其组合以及由其产生的抗体可用于预防，治疗和诊断WNV感染的免疫原性组合物中。 还描述了用于检测生物样品中WNV存在的高灵敏度ELISA和条带免疫测定方法。
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公开(公告)号：US08475808B2
公开(公告)日：2013-07-02
申请号：US10557427
申请日：2004-05-21
申请人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes , Yiu-Lian Fong
发明人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes , Yiu-Lian Fong
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/545 , A61K2039/55566 , C07K2319/02 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N33/6854 , G01N2333/18 , G01N2469/20 , Y02A50/394
摘要： Recombinant production of immunogenic West Nile Virus (WNV) proteins is described. These proteins, heterodimers comprising the proteins, fusions thereof, polynucleotides encoding the proteins, and combinations thereof, as well as antibodies produced therefrom, can be used in immunogenic compositions for preventing, treating and diagnosing WNV infection. Also described are highly sensitive ELISA and strip immunoassay methods for detecting the presence of WNV in biological samples.
摘要翻译： 描述了免疫原性西尼罗病毒（WNV）蛋白的重组产生。 包含蛋白质的这些蛋白质，其融合物，编码蛋白质的多核苷酸及其组合以及由其产生的抗体可用于预防，治疗和诊断WNV感染的免疫原性组合物中。 还描述了用于检测生物样品中WNV存在的高灵敏度ELISA和条带免疫测定方法。
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公开(公告)号：US20060292659A1
公开(公告)日：2006-12-28
申请号：US11193615
申请日：2005-08-01
申请人： David Chien , Mark Selby , Kevin Shoemaker , Robert Warne
发明人： David Chien , Mark Selby , Kevin Shoemaker , Robert Warne
IPC分类号： C12Q1/37
CPC分类号： C07K14/005 , C12N2770/24222 , C12Q1/025 , C12Q1/37 , G01N2333/18 , G01N2500/00
摘要： A polypeptide containing an anchor region, a protease recognition site, and a detectable signal region can be produced recombinantly and directly attached to a solid support. The polypeptide is useful for screening protease regulators, especially protease inhibitors.
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公开(公告)号：US20060257852A1
公开(公告)日：2006-11-16
申请号：US10822303
申请日：2004-04-09
申请人： Rino Rappuoli , Vega Masignani , Konrad Stadler , Jens Gregersen , David Chien , Jang Han , John Polo , Amy Weiner , Michael Houghton , Hyun Song , Mi-Young Seo , John Donnelly , Hans Klenk , Nicholas Valiante
发明人： Rino Rappuoli , Vega Masignani , Konrad Stadler , Jens Gregersen , David Chien , Jang Han , John Polo , Amy Weiner , Michael Houghton , Hyun Song , Mi-Young Seo , John Donnelly , Hans Klenk , Nicholas Valiante
IPC分类号： C12Q1/70 , C07H21/04 , C12N15/86 , C07K14/165
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/215 , A61K2039/5252 , A61K2039/545 , A61K2039/55505 , A61K2039/55511 , A61K2039/55566 , C07K16/10 , C07K2317/34 , C07K2317/76 , C07K2319/21 , C12N7/00 , C12N2770/20021 , C12N2770/20022 , C12N2770/20034 , C12N2770/20043 , C12N2770/20051 , C12N2770/20063 , C12Q1/701 , G01N2333/165 , G01N2469/20
摘要： An outbreak of a virulent respiratory virus, now known as Severe Acute Respiratory Syndrome (SARS), was identified in Hong Kong, China and a growing number of countries around the world in 2003. The invention relates to nucleic acids and proteins from the SARS coronavirus. These nucleic acids and proteins can be used in the preparation and manufacture of vaccine formulations, diagnostic reagents, kits, etc. The invention also provides methods for treating SARS by administering small molecule antiviral compounds, as well as methods of identifying potent small molecules for the treatment of SARS.
摘要翻译： 在2003年，中国香港和世界各地越来越多的国家确定了现在称为严重急性呼吸综合征（SARS）的毒性呼吸道病毒的爆发。本发明涉及SARS冠状病毒的核酸和蛋白质 。 这些核酸和蛋白质可用于制备和制造疫苗制剂，诊断试剂，试剂盒等。本发明还提供了通过施用小分子抗病毒化合物治疗SARS的方法，以及鉴定用于治疗SARS的有效小分子的方法 治疗SARS。
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公开(公告)号：US07491808B2
公开(公告)日：2009-02-17
申请号：US11213326
申请日：2005-08-26
申请人： David Chien , Doris Coit , Celine Hu , Sansan Lin , Angelica Medina-Selby
发明人： David Chien , Doris Coit , Celine Hu , Sansan Lin , Angelica Medina-Selby
IPC分类号： C07H21/04
CPC分类号： G01N33/5767 , C07K14/005 , C12N2770/24222
摘要： Modified HCV non-structural proteins are described. The proteins include modified NS3 domains such that proteolytic activity of the NS3 molecule is inhibited. The modified proteins retain conformational epitopes. HCV immunoassays including the modified NS3 molecules are also described.
摘要翻译： 描述了修饰的HCV非结构蛋白。 蛋白质包括修饰的NS3结构域，使得NS3分子的蛋白水解活性被抑制。 修饰的蛋白质保留构象表位。 还描述了包括经修饰的NS3分子的HCV免疫测定。
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公开(公告)号：US20070009516A1
公开(公告)日：2007-01-11
申请号：US10535635
申请日：2003-11-25
申请人： Uyen Tran , Thomas Richardson , Shanya Becha , Vicki Elliott , Anita Swarnakar , Soo Lee , Jayalaxmi Ramkumar , Jonathan Wang , David Chien , Jagi Murage , Mili Gera , Joseph Marquis , Narinder Chawla , Lisa Nakamura , Amy Kable
发明人： Uyen Tran , Thomas Richardson , Shanya Becha , Vicki Elliott , Anita Swarnakar , Soo Lee , Jayalaxmi Ramkumar , Jonathan Wang , David Chien , Jagi Murage , Mili Gera , Joseph Marquis , Narinder Chawla , Lisa Nakamura , Amy Kable
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , A61K39/395 , C12M1/34 , A01K67/00 , C07K14/705 , C07K16/28
CPC分类号： C07K14/47
摘要： Various embodiments of the invention provide human immune response associated proteins (IRAP) and polynucleotides which identify and encode IRAP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of IRAP.
摘要翻译： 本发明的各种实施方案提供鉴定和编码IRAP的人免疫应答相关蛋白（IRAP）和多核苷酸。 本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 其他实施方案提供用于诊断，治疗或预防与IRAP异常表达相关的紊乱的方法。
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公开(公告)号：US20070276126A1
公开(公告)日：2007-11-29
申请号：US10524355
申请日：2003-08-12
申请人： Vicki Elliott , Reena Khare , Brooke Emerling , Amy Kable , Uyen Tran , Pei Jin , Shanya Becha , Joseph Marquis , Anita Swarnakar , Narinder Chawla , Jayalaxmi Ramkumar , April Hafalia , Soo Lee , Xin Jiang , Alan Jackson , Thomas Richardson , Julie Blake , Jonathan Wang , David Chien , Yonghong Yang
发明人： Vicki Elliott , Reena Khare , Brooke Emerling , Amy Kable , Uyen Tran , Pei Jin , Shanya Becha , Joseph Marquis , Anita Swarnakar , Narinder Chawla , Jayalaxmi Ramkumar , April Hafalia , Soo Lee , Xin Jiang , Alan Jackson , Thomas Richardson , Julie Blake , Jonathan Wang , David Chien , Yonghong Yang
CPC分类号： C07K14/705 , Y02A90/26
摘要： Various embodiments of the invention provide human cell adhesion and extracellular matrix proteins (CADECM) and polynucleotides which identify and encode CADECM. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of CADECM.
摘要翻译： 本发明的各种实施方案提供了识别和编码CADECM的人细胞粘附和细胞外基质蛋白（CADECM）和多核苷酸。 本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 其他实施方案提供用于诊断，治疗或预防与CADECM异常表达相关的紊乱的方法。
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公开(公告)号：US20060121459A1
公开(公告)日：2006-06-08
申请号：US10504973
申请日：2003-02-18
申请人： Narinder Chawla , Henry Yue , Thomas Richardson , Joseph Marquis , Patricia Lehr-Mason , Ann Gorvad , Shanya Becha , Amy Kable , Anita Swarnakar , Pei Jin , Phillip Hawkins , David Chien , Jayalaxmi Ramkumar , Uyen Tran , April Hafalia , Mariah Baughn , Soo Lee , Xin Jiang , Alan Jackson , Reena Khare , Sean Bulloch
发明人： Narinder Chawla , Henry Yue , Thomas Richardson , Joseph Marquis , Patricia Lehr-Mason , Ann Gorvad , Shanya Becha , Amy Kable , Anita Swarnakar , Pei Jin , Phillip Hawkins , David Chien , Jayalaxmi Ramkumar , Uyen Tran , April Hafalia , Mariah Baughn , Soo Lee , Xin Jiang , Alan Jackson , Reena Khare , Sean Bulloch
CPC分类号： C07K14/705 , C07K16/28
摘要： Various embodiments of the invention provide human receptors and membrane-associated proteins (REMAP) and Q polynucleotides which identify and encode REMAP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of REMAP.
摘要翻译： 本发明的各种实施方案提供鉴定和编码REMAP的人受体和膜相关蛋白（REMAP）和Q多核苷酸。 本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 其他实施方案提供用于诊断，治疗或预防与REMAP异常表达相关的紊乱的方法。
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