发明授权
- 专利标题： Selection system
- 专利标题（中）： 选拔制度
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申请号： US09710444申请日： 2000-11-10
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公开(公告)号： US07442159B1公开(公告)日： 2008-10-28
- 发明人: Lutz Riechmann , Peter Kristensen , Jean-Luc Jestin , Gregory Paul Winter
- 申请人： Lutz Riechmann , Peter Kristensen , Jean-Luc Jestin , Gregory Paul Winter
- 申请人地址： GB Cambridge
- 专利权人： Domantis Limited
- 当前专利权人： Domantis Limited
- 当前专利权人地址： GB Cambridge
- 代理机构： Edwards Angell Palmer & Dodge LLP
- 代理商 Kathleen Williams
- 优先权： GB9810223.9 19980513; GB9810228.8 19980513
- 主分类号： C40B20/08
- IPC分类号： C40B20/08 ; C40B30/04 ; C12Q1/68 ; C40B40/02
摘要：
The present invention concerns a method for the selection of a virus comprising the steps of: (a) providing a virus encoding and displaying a fusion polypeptide, said fusion polypeptide comprising a heterologous polypeptide inserted into the sequence of a viral coat protein polypeptide, wherein said virus comprises a cleavable site located within a displayed polypeptide; (b) exposing the virus to a cleaving agent; (c) propagating the virus comprising intact fusion protein.
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