Invention Grant
- Patent Title: Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents
- Patent Title (中): 用干扰素拮抗功能鉴定病毒蛋白的筛选方法和潜在的抗病毒剂
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Application No.: US11375746Application Date: 2006-03-14
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Publication No.: US07442527B2Publication Date: 2008-10-28
- Inventor: Peter M. Palese , Adolfo Garcia-Sastre , Christopher Basler
- Applicant: Peter M. Palese , Adolfo Garcia-Sastre , Christopher Basler
- Applicant Address: US NY New York
- Assignee: Mount Sinai School of Medicine of New York University
- Current Assignee: Mount Sinai School of Medicine of New York University
- Current Assignee Address: US NY New York
- Agency: Jones Day
- Main IPC: C12P19/34
- IPC: C12P19/34 ; C12P21/04 ; A61K39/145
Abstract:
The present invention relates, in general, to a screening method for identifying novel viral proteins with interferon antagonizing function using a transfection-based assay, and the use of such proteins in isolating various types of attenuated viruses for the development of vaccine and pharmaceutical formulations. The invention also relates to the use of viral interferon antagonists in screening assays to identify potential anti-viral agents. The invention further relates to protocols utilizing interferon antagonists, e.g., NS1, to enhance gene therapy or DNA vaccination based on their ability to increase gene expression.
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