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    Chris-like virus, compositions, vaccines and uses thereof
    6.
    发明申请
    Chris-like virus, compositions, vaccines and uses thereof 审中-公开
    类似克里斯的病毒，组合物，疫苗及其用途

    公开(公告)号：US20060134610A1

    公开(公告)日：2006-06-22

    申请号：US10828564

    申请日：2004-04-21

    Applicant: Peter Palese ,  Adolfo Garcia-Sastre ,  Christopher Basler

    Inventor： Peter Palese ,  Adolfo Garcia-Sastre ,  Christopher Basler

    IPC: C12Q1/70 ,  G01N33/53 ,  C07H21/04 ,  C12N7/00 ,  C07K14/115

    CPC classification number: C07K14/005 ,  C12N7/00 ,  C12N2760/18021 ,  C12N2760/18022 ,  C12Q1/701

    Abstract: A novel virus, the Chris-like virus, has been identified and characterised. Sequences derived from a new paramyxovirus, Chris-like virus (CV), are provided. These sequences encode viral proteins with similarity to recognized viral proteins in other known and characterized paramyxoviruses. The CV viral sequences and the polypeptides encoded therein are useful for the detection, immunological protection and therapy of CV. The sequences provided by the invention are also useful for the isolation and characterization of CV, for the propagation of CV or its viral components in cells or tissue culture, for the generation of immunogenic polypeptides and vaccines, and for the screening and identification of antiviral agents for CV.

    Abstract translation: 一种新型病毒，类似克里斯的病毒，已被鉴定和表征。 提供了来自新的副粘病毒，克里斯样病毒（CV）的序列。 这些序列编码与其他已知和特征性的副粘病毒中识别的病毒蛋白相似的病毒蛋白。 CV病毒序列及其中编码的多肽可用于CV的检测，免疫保护和治疗。 本发明提供的序列也可用于分离和表征CV，用于在细胞或组织培养物中增殖CV或其病毒组分，用于产生免疫原性多肽和疫苗，以及用于筛选和鉴定抗病毒剂 简历。

    Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents
    8.
    发明授权
    Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents 有权
    用干扰素拮抗功能鉴定病毒蛋白的筛选方法和潜在的抗病毒剂

    公开(公告)号：US07833774B2

    公开(公告)日：2010-11-16

    申请号：US12218280

    申请日：2008-07-14

    Applicant: Peter M. Palese ,  Adolfo Garcia-Sastre ,  Christopher Basler

    Inventor： Peter M. Palese ,  Adolfo Garcia-Sastre ,  Christopher Basler

    IPC: C12N7/02 ,  C12N5/10

    CPC classification number: G01N33/5008 ,  C12N15/1086 ,  C12Q1/18 ,  G01N33/502 ,  G01N33/6866 ,  G01N2333/005 ,  G01N2333/115 ,  G01N2333/145

    Abstract: The present invention relates, in general, to a screening method for identifying novel viral proteins with interferon antagonizing function using a transfection-based assay, and the use of such proteins in isolating various types of attenuated viruses for the development of vaccine and pharmaceutical formulations. The invention also relates to the use of viral interferon antagonists in screening assays to identify potential anti-viral agents. The invention further relates to protocols utilizing interferon antagonists, e.g., NS1, to enhance gene therapy or DNA vaccination based on their ability to increase gene expression.

    Abstract translation: 本发明一般涉及使用基于转染的测定法鉴定具有干扰素拮抗功能的新型病毒蛋白的筛选方法，以及使用这些蛋白质分离各种类型的减毒病毒以开发疫苗和药物制剂。 本发明还涉及病毒干扰素拮抗剂在筛选测定中鉴定潜在的抗病毒剂的用途。 本发明进一步涉及利用干扰素拮抗剂（例如NS1）基于其增加基因表达能力来增强基因治疗或DNA疫苗接种的方案。

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