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发明授权
US07445929B2 Recombinant adenovirus vector having a reduced side effect 失效
具有降低的副作用的重组腺病毒载体

Recombinant adenovirus vector having a reduced side effect
摘要：
The present invention provides a novel adenovirus vector for which inflammation during the in vivo administration thereof is alleviated by inhibiting the induction of expression of an adenovirus gene by a foreign promoter inserted into the adenovirus genome, and a method for producing the vector, a cell line for use in the production of the recombinant adenovirus vector, or a gene therapy method using the recombinant adenovirus vector.
摘要（中）：

本发明提供了一种新的腺病毒载体，其通过抑制插入到腺病毒基因组中的外源启动子诱导腺病毒基因的表达来减轻其体内给药期间的炎症，以及生成载体的方法，细胞系 用于生产重组腺病毒载体，或使用重组腺病毒载体的基因治疗方法。

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