公开(公告)号：US20120020924A1

公开(公告)日：2012-01-26

申请号：US13152766

申请日：2011-06-03

申请人： Michio Nakai ,  Kazuo Komiya ,  Masashi Murata ,  Naoki Tohdoh ,  Izumu Saito

发明人： Michio Nakai ,  Kazuo Komiya ,  Masashi Murata ,  Naoki Tohdoh ,  Izumu Saito

IPC分类号： A61K48/00

CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2710/10361 ,  C12N2800/30

摘要： The present invention provides a novel adenovirus vector for which inflammation during the in vivo administration thereof is alleviated by inhibiting the induction of expression of an adenovirus gene by a foreign promoter inserted into the adenovirus genome, and a method for producing the vector, a cell line for use in the production of the recombinant adenovirus vector, or a gene therapy method using the recombinant adenovirus vector.

摘要翻译： 本发明提供了一种新的腺病毒载体，其通过抑制插入到腺病毒基因组中的外源启动子诱导腺病毒基因的表达来减轻其体内给药期间的炎症，以及生成载体的方法，细胞系 用于生产重组腺病毒载体，或使用重组腺病毒载体的基因治疗方法。

公开(公告)号：US07445929B2

公开(公告)日：2008-11-04

申请号：US10296716

申请日：2001-05-24

申请人： Michio Nakai ,  Kazuo Komiya ,  Masashi Murata ,  Naoki Tohdoh ,  Izumu Saito

发明人： Michio Nakai ,  Kazuo Komiya ,  Masashi Murata ,  Naoki Tohdoh ,  Izumu Saito

IPC分类号： C12N15/861 ,  C12N7/01 ,  A61K48/00 ,  A61K31/713 ,  A01N63/00

CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2710/10361 ,  C12N2800/30

摘要： The present invention provides a novel adenovirus vector for which inflammation during the in vivo administration thereof is alleviated by inhibiting the induction of expression of an adenovirus gene by a foreign promoter inserted into the adenovirus genome, and a method for producing the vector, a cell line for use in the production of the recombinant adenovirus vector, or a gene therapy method using the recombinant adenovirus vector.

摘要翻译： 本发明提供了一种新的腺病毒载体，其通过抑制插入到腺病毒基因组中的外源启动子诱导腺病毒基因的表达来减轻其体内给药期间的炎症，以及生成载体的方法，细胞系 用于生产重组腺病毒载体，或使用重组腺病毒载体的基因治疗方法。

公开(公告)号：US08591879B2

公开(公告)日：2013-11-26

申请号：US13152766

申请日：2011-06-03

申请人： Michio Nakai ,  Kazuo Komiya ,  Masashi Murata ,  Naoki Tohdoh ,  Izumu Saito

发明人： Michio Nakai ,  Kazuo Komiya ,  Masashi Murata ,  Naoki Tohdoh ,  Izumu Saito

IPC分类号： A61K48/00 ,  A01N63/00

CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2710/10361 ,  C12N2800/30

摘要： The present invention provides a novel adenovirus vector for which inflammation during the in vivo administration thereof is alleviated by inhibiting the induction of expression of an adenovirus gene by a foreign promoter inserted into the adenovirus genome, and a method for producing the vector, a cell line for use in the production of the recombinant adenovirus vector, or a gene therapy method using the recombinant adenovirus vector.

摘要翻译： 本发明提供了一种新的腺病毒载体，其通过抑制插入到腺病毒基因组中的外源启动子诱导腺病毒基因的表达来减轻其体内给药期间的炎症，以及生成载体的方法，细胞系 用于重组腺病毒载体的生产，或使用重组腺病毒载体的基因治疗方法。

公开(公告)号：US20090104691A1

公开(公告)日：2009-04-23

申请号：US12211321

申请日：2008-09-16

申请人： Michio Nakai ,  Kazuo Komiya ,  Masashi Murata ,  Naoki Tohdoh ,  Izumu Saito

发明人： Michio Nakai ,  Kazuo Komiya ,  Masashi Murata ,  Naoki Tohdoh ,  Izumu Saito

IPC分类号： C12N15/00

CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2710/10361 ,  C12N2800/30

摘要： The present invention provides a novel adenovirus vector for which inflammation during the in vivo administration thereof is alleviated by inhibiting the induction of expression of an adenovirus gene by a foreign promoter inserted into the adenovirus genome, and a method for producing the vector, a cell line for use in the production of the recombinant adenovirus vector, or a gene therapy method using the recombinant adenovirus vector.

摘要翻译： 本发明提供了一种新的腺病毒载体，其通过抑制插入到腺病毒基因组中的外源启动子诱导腺病毒基因的表达来减轻其体内给药期间的炎症，以及生成载体的方法，细胞系 用于生产重组腺病毒载体，或使用重组腺病毒载体的基因治疗方法。

公开(公告)号：US5901679A

公开(公告)日：1999-05-11

申请号：US951732

申请日：1997-10-16

申请人： Shigekazu Tanaka ,  Takashi Taguchi ,  Shigemasa Kajiwara ,  Masashi Murata ,  Atsushi Iwamoto ,  Toshinari Sonoda ,  Masahiko Tashiro ,  Yasuyuki Kimura ,  Kaoru Aoki ,  Mitsuo Takashima

发明人： Shigekazu Tanaka ,  Takashi Taguchi ,  Shigemasa Kajiwara ,  Masashi Murata ,  Atsushi Iwamoto ,  Toshinari Sonoda ,  Masahiko Tashiro ,  Yasuyuki Kimura ,  Kaoru Aoki ,  Mitsuo Takashima

IPC分类号： F01M11/00 ,  F02F7/00

CPC分类号： F02F7/0053 ,  F01M11/0004 ,  F02B2275/20 ,  F02F2007/0063 ,  F02F2200/06 ,  F05C2201/021 ,  F05C2201/0439

摘要： In an engine for a vehicle including a bearing cap integral type oil pan which has a plurality of bearing cap sections integrally provided thereon and which is integrally coupled to a cylinder block, connecting bolts are screwed into the bearing cap sections from the cylinder block to integrally couple the cylinder block and the oil pan to each other. An oil pan chamber, which is an as-cast bore made by drawing a die in an axial direction of a crankshaft, is defined to extend continuously in the axial direction of the crankshaft between the bearing cap sections and a bottom wall of the oil pan. Thus, the oil pan can be produced simply, at a low cost, by a casting process and moreover, it is possible to reduce the weight and size of the oil pan and increase the rigidity of the oil pan.

摘要翻译： 在一种用于车辆的发动机中，包括具有一体地设置在其上的多个轴承盖部分的轴承盖一体式油盘，并且其一体地联接到气缸体，连接螺栓从气缸体螺纹连接到轴承盖部分中以一体地 将气缸体和油盘相互连接。 油盘室是通过在曲轴的轴向上拉模而制成的铸造孔，被定义为在轴承盖部分和油盘的底壁之间在曲轴的轴向方向上连续地延伸 。 因此，油底壳可以通过铸造方法简单地以低成本制造，并且还可以减小油盘的重量和尺寸并增加油盘的刚性。

公开(公告)号：US5125935A

公开(公告)日：1992-06-30

申请号：US613702

申请日：1990-11-26

申请人： Keiichi Nakaya ,  Masashi Murata ,  Masaaki Shimizu

发明人： Keiichi Nakaya ,  Masashi Murata ,  Masaaki Shimizu

IPC分类号： B01D53/04

CPC分类号： B01D53/0454 ,  B01D53/04 ,  B01D2257/302 ,  B01D2257/406 ,  B01D2257/702 ,  B01D2259/403

摘要： The method of the present invention is one for efficiently obtaining a condensed adsorbable gas from a gas containing a low concentration of the adsorbable gas by subjecting the original gas to the process of adsorption and desorption using adsorption columns packed with an adsorbent and then condensing the exhausted desorbed gas containing a higher concentration of the adsorbable gas, in which the adsorption column after adsorption is subjected to desorption after a desorbed gas exhausted from the second adsorption column to be mentioned later is introduced into the adsorption column to make the adsorbable gas contained in the desorbed gas be adsorbed by the column; an exhaust gas exhausted during the condensation of a desorbed gas and containing the noncondensed adsorbable gas is introduced into the second adsorption column to make the adsorbable gas contained in the exhaust gas be adsorbed by the column; and the desorbed gas containing the adsorbable gas and exhausted during the desorption of the second column which is performed in the next operation of adsorption and desorption is introduced into the adsorption column after adsorption. This method is excellent because of a simple operation, and a small thermal energy required during desorption.

摘要翻译： PCT No.PCT / JP90 / 00343 Sec。 371日期1990年11月26日 102（e）1990年11月26日日期PCT 1990年3月15日PCT PCT。 出版物WO90 / 11117 日本1990年10月4日。本发明的方法是一种用于通过使原始气体进行吸附和解吸的过程，用含有低浓度可吸附气体的气体有效地获得冷凝的可吸附气体， 然后使含有较高浓度可吸附气体的排出的脱附气体冷凝，吸附后的吸附塔在从后述的第二吸附塔排出的解吸气体被吸入后进行解吸， 使解吸气体中所含的可吸附气体被柱吸附; 在脱附气体的冷凝中排出并含有非凝结的可吸附气体的排气被引入第二吸附塔，使废气中所含的可吸附气体被塔吸附; 在吸附和解吸的下一次操作中进行的第二塔的解吸时，含有可吸附气体的解吸气体被排出，吸附后被引入吸附塔。 该方法由于操作简单，解吸过程中所需的热能小，因而极好。

公开(公告)号：US06523456B1

公开(公告)日：2003-02-25

申请号：US09763612

申请日：2001-05-03

申请人： Shigemi Kobayashi ,  Masashi Murata ,  Hidemi Ogihara ,  Hiroshi Yamada ,  Kazuhisa Ishizuka ,  Sakae Tsunashima

发明人： Shigemi Kobayashi ,  Masashi Murata ,  Hidemi Ogihara ,  Hiroshi Yamada ,  Kazuhisa Ishizuka ,  Sakae Tsunashima

IPC分类号： F01B3110

CPC分类号： F16J10/04 ,  F01M2001/083 ,  F02F3/00 ,  F16N7/16

摘要： A sliding surface of at least one of sliding members sliding with respect to each other in a sliding direction comprises a protrusion extending along a direction intersecting the sliding direction and fine dimples provided on a surface of the protrusion. In the sliding members, lubricating oil is accumulated in the dimples, and is easily extracted through a drain portion formed by dimple in a running-in operation.

摘要翻译： 至少一个在滑动方向上相对滑动的滑动构件的滑动表面包括沿着与滑动方向相交的方向延伸的突起和设置在突出部的表面上的细小凹坑。 在滑动构件中，润滑油积聚在凹坑中，并且在通入操作中容易地通过由凹坑形成的排水部分提取。

公开(公告)号：US6158402A

公开(公告)日：2000-12-12

申请号：US161302

申请日：1998-09-28

申请人： Takashi Taguchi ,  Sigemi Kobayashi ,  Toshinari Sonoda ,  Atsushi Iwamoto ,  Hirokazu Osaki ,  Shigemasa Kajiwara ,  Shigekazu Tanaka ,  Kazuo Shibata ,  Masashi Murata ,  Masahiko Tashiro ,  Sumiko Watanabe ,  Kazuhisa Ishizuka

发明人： Takashi Taguchi ,  Sigemi Kobayashi ,  Toshinari Sonoda ,  Atsushi Iwamoto ,  Hirokazu Osaki ,  Shigemasa Kajiwara ,  Shigekazu Tanaka ,  Kazuo Shibata ,  Masashi Murata ,  Masahiko Tashiro ,  Sumiko Watanabe ,  Kazuhisa Ishizuka

IPC分类号： F02B75/18 ,  F02B75/22 ,  F02F7/00 ,  F16C9/02 ,  F02B75/20

CPC分类号： F16C9/02 ,  F02B75/221 ,  F02F7/0007 ,  F02B2075/1816 ,  F02B2275/20

摘要： In an engine block structure in a multi-cylinder engine in which a piston is incorporated from the side of a crank chamber into each of a plurality of cylinders disposed in series in a cylinder block, cylinder axes of the two adjacent cylinders are disposed to extend in such directions that they are gradually spaced apart from each other as proceeding from the side of a valve operating chamber toward the crank chamber as viewed from a direction of arrangement of the cylinders. Thus, a sufficient crankshaft bearing area can be ensured without bringing an increase in number of parts and an increase in size of the engine block.

摘要翻译： 在多缸发动机的发动机缸体结构中，活塞从曲轴室侧并入设置在气缸体中的多个气缸中的每一个中，两个相邻气缸的气缸轴线被设置为延伸 在从气缸的排列方向观察时，从阀操作室侧向曲柄室方向逐渐间隔开的方向。 因此，可以确保足够的曲轴轴承面积，而不会增加零件数量和增加发动机缸体的尺寸。

公开(公告)号：US6116364A

公开(公告)日：2000-09-12

申请号：US151027

申请日：1998-09-10

申请人： Takashi Taguchi ,  Masashi Murata ,  Hirokazu Ohsaki

发明人： Takashi Taguchi ,  Masashi Murata ,  Hirokazu Ohsaki

IPC分类号： B60K17/04 ,  B60K5/04 ,  B60K6/20 ,  B60K6/24 ,  B60K6/26 ,  B60K6/36 ,  B60K6/40 ,  B60K6/405 ,  B60K6/485 ,  B60K6/54 ,  B60K17/02 ,  B60L11/14 ,  F01M11/00 ,  F02B43/10 ,  F02B75/18 ,  F02B75/20 ,  F02D29/02 ,  F02F7/00 ,  H02K7/00 ,  B60K1/00

CPC分类号： B60K6/24 ,  B60K6/405 ,  B60K6/485 ,  B60K6/54 ,  B60L11/005 ,  B60L11/14 ,  B60L11/1868 ,  B60L15/20 ,  F01M11/0004 ,  F02B43/10 ,  F02B75/20 ,  H02K7/006 ,  B60K17/02 ,  B60K5/04 ,  B60L2210/12 ,  B60L2240/421 ,  B60L2260/26 ,  F02B2075/1812 ,  Y02T10/32 ,  Y02T10/6226 ,  Y02T10/6295 ,  Y02T10/641 ,  Y02T10/645 ,  Y02T10/70 ,  Y02T10/7005 ,  Y02T10/7022 ,  Y02T10/7066 ,  Y02T10/7077 ,  Y02T10/7233 ,  Y02T10/7275 ,  Y10S903/903 ,  Y10S903/905 ,  Y10S903/906 ,  Y10S903/909 ,  Y10S903/917 ,  Y10S903/951 ,  Y10S903/952

摘要： A housing of a motor generator is integrally coupled to an end of an internal combustion engine. The internal combustion engine includes an oil pan and a cylinder block which have arcuate stiffener ribs and radial stiffener ribs on end surfaces thereof for increased mechanical strength of the internal combustion engine. The motor generator has a housing that is directly coupled to the internal combustion engine with a relatively small number of parts.

摘要翻译： 电动发电机的壳体整体地联接到内燃机的端部。 内燃机包括油盘和气缸体，其在其端面上具有弓形加强肋和径向加强筋，以增加内燃机的机械强度。 电动发电机具有壳体，其以相对较少数量的部件直接联接到内燃机。

公开(公告)号：US4929372A

公开(公告)日：1990-05-29

申请号：US356795

申请日：1989-05-23

申请人： Hideo Akanuma ,  Masashi Murata ,  Kiyoshi Inoue ,  Ryoji Ohgake

发明人： Hideo Akanuma ,  Masashi Murata ,  Kiyoshi Inoue ,  Ryoji Ohgake

IPC分类号： C10M111/02 ,  C10M169/04 ,  C10N30/08 ,  C10N40/32

CPC分类号： C10M169/04 ,  C10M2201/041 ,  C10M2201/042 ,  C10M2207/281 ,  C10M2207/282 ,  C10M2207/283 ,  C10M2207/2835 ,  C10M2207/286 ,  C10M2209/109 ,  C10N2240/00 ,  C10N2240/22 ,  C10N2240/30 ,  C10N2240/50 ,  C10N2240/52 ,  C10N2240/54 ,  C10N2240/56 ,  C10N2240/58 ,  C10N2240/60 ,  C10N2240/66

摘要： A lubricating oil composition for chains which comprises(A) as the base oil, a polyol ester represented by the general formula ##STR1## wherein R.sub.1 is an alkyl group having 1 to 4 carbon atoms, R.sub.2 to R.sub.4 are each an alkyl group having 2 to 17 carbon atoms, a and b are each an integer of 0 to 2 with the proviso that the total of a and b is 2, and n is an integer of 1 to 4, and(B) as an additive, a graphite fluoride represented by the experimental formulaCF.sub.x wherein x is a number of 0.5 to 1.2, in a specified amount of 0.5 to 30% by weight of the composition.

摘要翻译： 一种用于链的润滑油组合物，其包含（A）作为基油，由通式“IMAGE”表示的多元醇酯，其中R 1为具有1至4个碳原子的烷基，R 2至R 4各自为具有2个 至17个碳原子，a和b各自为0至2的整数，条件是a和b的总数为2，n为1〜4的整数，（B）作为添加剂，氟化石墨 由实验式CF x表示，其中x为0.5至1.2的数量，以组合物的0.5至30重量％的指定量表示。