发明授权
US07449569B2 Isolated fungal promoters and gene transcription terminators and methods of protein and chemical production in a fungus
失效
分离的真菌启动子和基因转录终止子以及真菌中蛋白质和化学生产的方法
- 专利标题： Isolated fungal promoters and gene transcription terminators and methods of protein and chemical production in a fungus
- 专利标题（中）： 分离的真菌启动子和基因转录终止子以及真菌中蛋白质和化学生产的方法
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申请号： US10920625申请日： 2004-08-17
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公开(公告)号： US07449569B2公开(公告)日： 2008-11-11
- 发明人: Ziyu Dai , Linda L. Lasure , Jon K. Magnuson
- 申请人： Ziyu Dai , Linda L. Lasure , Jon K. Magnuson
- 申请人地址： US WA Richland
- 专利权人： Battelle Memorial Institute
- 当前专利权人： Battelle Memorial Institute
- 当前专利权人地址： US WA Richland
- 代理机构： Wells St. John P.S.
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C12Q1/68 ; C12N15/00 ; C12N15/63 ; C12N1/00
摘要：
The present invention encompasses isolated gene regulatory elements and gene transcription terminators that are differentially expressed in a native fungus exhibiting a first morphology relative to the native fungus exhibiting a second morphology. The invention also encompasses a method of utilizing a fungus for protein or chemical production. A transformed fungus is produced by transforming a fungus with a recombinant polynucleotide molecule. The recombinant polynucleotide molecule contains an isolated polynucleotide sequence linked operably to another molecule comprising a coding region of a gene of interest. The gene regulatory element and gene transcription terminator may temporally and spatially regulate expression of particular genes for optimum production of compounds of interest in a transgenic fungus.
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