发明授权
US07459460B2 Trisubstituted heteroaromatic compounds as calcium sensing receptor modulators
有权
三取代杂芳族化合物作为钙敏感受体调节剂
- 专利标题： Trisubstituted heteroaromatic compounds as calcium sensing receptor modulators
- 专利标题（中）： 三取代杂芳族化合物作为钙敏感受体调节剂
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申请号： US10854484申请日： 2004-05-26
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公开(公告)号： US07459460B2公开(公告)日： 2008-12-02
- 发明人: Wu Yang , John K. Dickson , Christopher B. Cooper , Dharmpal S. Dodd , Zheming Ruan , Dora M. Schnur
- 申请人： Wu Yang , John K. Dickson , Christopher B. Cooper , Dharmpal S. Dodd , Zheming Ruan , Dora M. Schnur
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Burton Rodney; Maureen S. Gibbons
- 主分类号： C07D213/36
- IPC分类号： C07D213/36 ; C07D239/42 ; C07D401/04 ; C07D403/04 ; A61K31/4418 ; A61K31/444 ; A61K31/505 ; A61K31/506
摘要：
Trisubstituted heteroaromatic compounds having the structure are provided, wherein X is C or N; A and B are each independently CH or N, with the proviso that A and B cannot both be CH; R1 is Ar-L-; R2 is hydrogen or alkyl; or R1 and R2 can be joined together to form a 4- to 7-membered cycloheteroalkyl ring; R3 to R8, Ar and L are as defined herein. A method for using these compounds to treat diseases associated with abnormal bone or mineral homeostasis is also provided.