发明授权
- 专利标题： Methods for evaluating susceptibility to a bone homeostasis disorder
- 专利标题（中）： 评价骨平衡障碍易感性的方法
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申请号： US10467033申请日： 2002-02-01
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公开(公告)号： US07462447B2公开(公告)日： 2008-12-09
- 发明人: Valdenize Tiziani , Ernst Reichenberger , Yasuyoshi Ueki , Bjorn R. Olsen
- 申请人： Valdenize Tiziani , Ernst Reichenberger , Yasuyoshi Ueki , Bjorn R. Olsen
- 申请人地址： US MA Cambridge
- 专利权人： President and Fellows of Harvard College
- 当前专利权人： President and Fellows of Harvard College
- 当前专利权人地址： US MA Cambridge
- 代理机构： Wolf, Greenfield & Sacks, P.C.
- 国际申请： PCT/US02/19164 WO 20020201
- 国际公布： WO03/025197 WO 20030327
- 主分类号： C12P1/68
- IPC分类号： C12P1/68 ; C12P19/34 ; C12N9/00 ; C07H21/04 ; C07K1/00
摘要：
The invention provides mutant SH3-binding protein (SH3BP2) nucleic acids, polypeptides, and agents which selectively bind to the mutant SH3BP2 molecules and which do not bind to the wild type SH3BP2 molecules. Methods for selecting agents which inhibit mutant SH3BP2 expression, as well as diagnostic and therapeutic methods which utilize the mutant SH3BP2 molecules for diagnosing and treating disorders of bone homeostasis, also are provided.
公开/授权文献
- US20060019248A1 Mutant sh-3 binding protein compositions and methods 公开/授权日：2006-01-26
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