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公开(公告)号：US07462447B2
公开(公告)日：2008-12-09
申请号：US10467033
申请日：2002-02-01
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , C07K14/51 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The invention provides mutant SH3-binding protein (SH3BP2) nucleic acids, polypeptides, and agents which selectively bind to the mutant SH3BP2 molecules and which do not bind to the wild type SH3BP2 molecules. Methods for selecting agents which inhibit mutant SH3BP2 expression, as well as diagnostic and therapeutic methods which utilize the mutant SH3BP2 molecules for diagnosing and treating disorders of bone homeostasis, also are provided.
摘要翻译： 本发明提供了选择性结合突变体SH3BP2分子并且不结合野生型SH3BP2分子的突变SH3结合蛋白（SH3BP2）核酸，多肽和试剂。 还提供了选择抑制突变体SH3BP2表达的药剂的方法，以及利用突变型SH3BP2分子诊断和治疗骨稳态障碍的诊断和治疗方法。
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公开(公告)号：US06899915B2
公开(公告)日：2005-05-31
申请号：US09997734
申请日：2001-11-29
CPC分类号： A61L27/3804 , A61K6/087 , A61K6/10 , A61L27/18 , A61L27/3865 , C08L67/04 , C08L51/085
摘要： Tooth tissues include the pulp mesenchyme that forms the dentin and an epithelium that is responsible for enamel formation. Cells from these tissues were obtained from porcine third molars and were seeded onto a biodegradable scaffold composed of a polyglycolic acid—polylactic acid copolymer. Cell polymer constructs were then surgically implanted into the omentum of athymic nude rats so that the constructs would have a blood supply and these tissues were allowed to develop inside the rats. Infrequently, columnar epithelial cells were observed as a single layer on the outside of the dentin-like matrix similar to the actual arrangement of ameloblasts over dentin during early tooth development. Developing tooth tissues derived from such cell polymer constructs could eventually be surgically implanted into the gum of an edentulous recipient where the construct would receive a blood supply and develop to maturity, providing the recipient with a biological tooth replacement.
摘要翻译： 牙组织包括形成牙本质的牙髓间质和负责牙釉质形成的上皮。 来自这些组织的细胞从猪第三磨牙获得，并且接种到由聚乙醇酸 - 聚乳酸共聚物组成的可生物降解的支架上。 然后将细胞聚合物构建体手术植入无胸腺裸鼠的网膜中，使得构建体将具有血液供应，并且允许这些组织在大鼠内部发育。 不常见的是，柱状上皮细胞在牙质样基质的外侧被看作单层，类似于早期牙齿发育过程中釉质在牙本质上的实际布置。 来自这样的细胞聚合物构建体的牙齿组织的发育最终可以被手术植入无牙细胞受体的牙龈中，其中构建体将接受血液供应并发育成熟，从而为受体提供生物牙齿置换。
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公开(公告)号：US5643783A
公开(公告)日：1997-07-01
申请号：US159784
申请日：1993-12-01
申请人： Bjorn R. Olsen , Suk P. Oh
发明人： Bjorn R. Olsen , Suk P. Oh
CPC分类号： C07K14/78
摘要： The invention features a novel collagen, type .alpha.1 (XVIII) collagen, and uses therefor.
摘要翻译： 本发明的特征在于一种新型胶原蛋白，α1型（XVIII）型胶原蛋白，并用于其中。
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公开(公告)号：US5374515A
公开(公告)日：1994-12-20
申请号：US974740
申请日：1992-11-13
CPC分类号： A61L27/3891 , A61F2/14 , A61F2/142 , A61K35/12 , A61L27/3804 , A61L27/3808 , A61L27/3813 , A61L27/3839 , A61L27/3895 , C12N5/0621 , C12N5/0697 , A61L2430/16 , C12N2500/25 , C12N2501/39 , C12N2501/395 , C12N2502/085 , C12N2502/094 , C12N2502/1323 , C12N2510/04 , C12N2533/54
摘要： This invention is directed to an organ equivalent of the cornea part of the eye made using tissue culturing systems. The method of constructing the cornea equivalent results in a structure analogous to the eye cornea in vivo. The cornea equivalent is an in vitro model of the eye, which can be used for transplantation or implantation in vivo or for screening compounds in vitro.
摘要翻译： 本发明涉及使用组织培养系统制造的眼睛的角膜部分的器官当量。 构建角膜等价物的方法产生类似于眼内角膜的结构。 角膜等效物是眼的体外模型，其可用于体内移植或植入或用于体外筛选化合物。
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