发明授权
- 专利标题: Optical determination of glucose utilizing boronic acid adducts
- 专利标题(中): 使用硼酸加合物光学测定葡萄糖
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申请号: US11296898申请日: 2005-12-07
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公开(公告)号: US07470420B2公开(公告)日: 2008-12-30
- 发明人: Bakthan Singaram , Ritchie A. Wessling
- 申请人: Bakthan Singaram , Ritchie A. Wessling
- 申请人地址: US CA Oakland
- 专利权人: The Regents of the University of California
- 当前专利权人: The Regents of the University of California
- 当前专利权人地址: US CA Oakland
- 代理机构: Biotechnology Law Group
- 主分类号: A61B10/00
- IPC分类号: A61B10/00 ; A61B5/00 ; A61B8/00
摘要:
The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.