发明授权
- 专利标题: Cancer cell targeting gene delivery method
- 专利标题(中): 癌细胞靶向基因递送方法
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申请号: US10578839申请日: 2004-03-15
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公开(公告)号: US07473430B2公开(公告)日: 2009-01-06
- 发明人: Yeon-Soo Kim , In Seop So , Young-Kwan Lee , Jongpil Kim , Moonkyung Kang , Hyojeong Hong
- 申请人: Yeon-Soo Kim , In Seop So , Young-Kwan Lee , Jongpil Kim , Moonkyung Kang , Hyojeong Hong
- 申请人地址: KR
- 专利权人: Inje University
- 当前专利权人: Inje University
- 当前专利权人地址: KR
- 代理机构: Sughrue Mion, PLLC
- 优先权: KR10-2003-0079897 20031112
- 国际申请: PCT/KR2004/000545 WO 20040315
- 国际公布: WO2005/047338 WO 20050526
- 主分类号: A61K35/12
- IPC分类号: A61K35/12 ; C12Q1/68
摘要:
The inventive chimeric ligand in the form of a fusion polypeptide of a single-chain antibody specific for Tag-72 surface antigen and GaLV envelope glycoprotein shows high transduction efficiency to cancer cells, specifically infects target cells and efficiently delivers a therapeutic gene. Accordingly, the inventive chimeric ligand can be effectively used for gene therapy to inhibit tumor growth and metastasis.
公开/授权文献
- US20070244032A1 Cancer Cell Targeting Gene Delivery Method 公开/授权日:2007-10-18
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