- 专利标题： N-heterocyclic inhibitors of TNF-α expression
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申请号： US11143430申请日： 2005-06-02
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公开(公告)号： US07479495B2公开(公告)日： 2009-01-20
- 发明人: Kevin Joseph Moriarty , Yvonne Shimshock , Gulzar Ahmed , Junjun Wu , James Wen , Wei Li , Shawn David Erickson , Jeffrey John Letourneau , Edward McDonald , Katerina Leftheris , Stephen T. Wrobleski , Zahid Hussain , Ian Henderson , Axel Metzger , John J. Baldwin , Alaric J. Dyckman
- 申请人： Kevin Joseph Moriarty , Yvonne Shimshock , Gulzar Ahmed , Junjun Wu , James Wen , Wei Li , Shawn David Erickson , Jeffrey John Letourneau , Edward McDonald , Katerina Leftheris , Stephen T. Wrobleski , Zahid Hussain , Ian Henderson , Axel Metzger , John J. Baldwin , Alaric J. Dyckman
- 申请人地址： US NJ Cranbury US NJ Princeton
- 专利权人： Pharmacopeia, Inc.,Bristol-Myers Squibb Company
- 当前专利权人： Pharmacopeia, Inc.,Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Cranbury US NJ Princeton
- 代理商 Laurelee A. Duncan; Rosemary M. Miano
- 主分类号： C07D239/32
- IPC分类号： C07D239/32 ; C07D239/48 ; C07D239/50 ; C07D401/04 ; C07D401/12 ; C07D403/04 ; C07D403/12 ; A61K31/505 ; A61K31/506 ; A61P19/02 ; A61P35/00
摘要：
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.
公开/授权文献
- US20050239770A1 N-heterocyclic inhibitors of TNF-alpha expression 公开/授权日：2005-10-27
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