摘要:
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.
摘要:
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.
摘要:
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.
摘要:
Compounds of the formula are disclosed as Mnk2 inhibitors which are useful for the treatment and prevention of metabolic disorders such as obesity and diabetes.
摘要:
Compounds of the formula wherein R1 represents optionally substituted C1-C10 alkyl, aryl or heteroaryl, and R3 represents alkoxy-substituted aryl or optionally substituted heteroaryl, are disclosed as Mnk2 inhibitors which are useful for the treatment and prevention of metabolic disorders such as obesity and diabetes.
摘要:
Compounds of the formula are disclosed as Mnk2 inhibitors which are useful for the treatment and prevention of metabolic disorders such as obesity and diabetes.
摘要:
Included are embodiments for processing video data. At least one embodiment includes receive logic configured to receive the video data chosen from a plurality of formats and filter logic configured to filter the video data according to the instruction. Similarly, some embodiments include transform logic configured to transform the video data according to the instruction, where the instruction contains a mode indication in which the filter logic and the transform logic execute based on the format of the video data.
摘要:
A content player transmits a screen image to a display. The screen image includes an active region, which may be a portion that may be manipulated. The player determines active region information for the active region and transmits such to a portable device. The portable device receives the active region information as well as information regarding any inactive regions, which may be portions that may not be manipulated. The portable device utilizes the information to present a simulated version of the screen image on a touch screen. The portable device may then receive manipulation information via the touch screen and transmit such to the player. In response, the player may generate and present an updated version of the screen image, determine updated information, and transmit such to the portable device. The portable device may utilize the updated information to present a simulated updated version of the screen image.
摘要:
Substituted spirocyclic amines of structural formula (I) are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, Metabolic Syndrome, depression, and anxiety.
摘要:
Disclosed is a graphics processing unit comprising an instruction decoder and sum-of-absolute-differences (SAD) accleration logic. The instruction decoder is configured to decode a SAD instruction into parameters describing an M×N and an n×n pixel block in U,V coordinates. The SAD accleration logic is configured to receive the parameters and compute SAD scores. Each SAD score corresponds to the n×n block and to one block contained within the M×N pixel block and horizontally offset within the n×n block. Also disclosed is a GPU comprising a host processor interface receiving video acceleration instructions and a video acceleration unit. The unit is responsive to the instructions and comprises SAD accleration logic configured to receive the parameters and compute SAD scores. Each SAD score corresponds to an n×n pixel block and to one block contained within an M×N block and horizontally offset within the n×n block. M, N, and n are integers.