发明授权
US07482437B2 Protease inhibitor conjugates and antibodies useful in immunoassay
失效
蛋白酶抑制剂缀合物和抗体可用于免疫测定
- 专利标题： Protease inhibitor conjugates and antibodies useful in immunoassay
- 专利标题（中）： 蛋白酶抑制剂缀合物和抗体可用于免疫测定
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申请号： US11670467申请日： 2007-02-02
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公开(公告)号： US07482437B2公开(公告)日： 2009-01-27
- 发明人: Gerald F. Sigler , Raymond A. Hui , Ina Deras , Richard Terry Root , Mitali Ghoshal , Erasmus Huber , Herbert W. Von Der Eltz , Sigrun Metz , Peter Kern
- 申请人： Gerald F. Sigler , Raymond A. Hui , Ina Deras , Richard Terry Root , Mitali Ghoshal , Erasmus Huber , Herbert W. Von Der Eltz , Sigrun Metz , Peter Kern
- 申请人地址： US IN Indianapolis
- 专利权人： Roche Diagnostics Operations, Inc.
- 当前专利权人： Roche Diagnostics Operations, Inc.
- 当前专利权人地址： US IN Indianapolis
- 代理机构： Roche Diagnostics Operations, Inc.
- 代理商 Marilyn Amick
- 主分类号： C07K17/06
- IPC分类号： C07K17/06 ; C07K1/10 ; C07K16/00 ; C07D403/02 ; C07D241/04
摘要：
Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.