发明授权
- 专利标题： Muteins of fibroblast growth factor 21
- 专利标题（中）： 成纤维细胞生长因子21的突变蛋白
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申请号： US10579510申请日： 2004-12-01
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公开(公告)号： US07491697B2公开(公告)日： 2009-02-17
- 发明人: John Michael Beals , Christopher Carl Frye , Wolfgang Glaesner , Shun Li , Radhakrishnan Rathnachalam , Jing Shang , Beth Ann Strifler , Radmila Micanovic
- 申请人： John Michael Beals , Christopher Carl Frye , Wolfgang Glaesner , Shun Li , Radhakrishnan Rathnachalam , Jing Shang , Beth Ann Strifler , Radmila Micanovic
- 申请人地址： US IN Indianapolis
- 专利权人： Eli Lilly and Company
- 当前专利权人： Eli Lilly and Company
- 当前专利权人地址： US IN Indianapolis
- 代理商 Lynn D. Apelgren
- 国际申请： PCT/US2004/037200 WO 20041201
- 国际公布： WO2005/061712 WO 20050707
- 主分类号： C07K14/50
- IPC分类号： C07K14/50 ; A61K38/18
摘要：
The present invention relates to novel muteins of human fibroblast growth factor 21 with improved pharmaceutical properties. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, metabolic syndrome, and in reducing the mortality and morbidity of critically ill patients.
公开/授权文献
- US20070142278A1 Muteins of fibroblast growth factor 21 公开/授权日：2007-06-21