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公开(公告)号：US07491697B2
公开(公告)日：2009-02-17
申请号：US10579510
申请日：2004-12-01
申请人： John Michael Beals , Christopher Carl Frye , Wolfgang Glaesner , Shun Li , Radhakrishnan Rathnachalam , Jing Shang , Beth Ann Strifler , Radmila Micanovic
发明人： John Michael Beals , Christopher Carl Frye , Wolfgang Glaesner , Shun Li , Radhakrishnan Rathnachalam , Jing Shang , Beth Ann Strifler , Radmila Micanovic
摘要： The present invention relates to novel muteins of human fibroblast growth factor 21 with improved pharmaceutical properties. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, metabolic syndrome, and in reducing the mortality and morbidity of critically ill patients.
摘要翻译： 本发明涉及具有改善的药物性质的人成纤维细胞生长因子21的新颖突变蛋白。 公开了蛋白质和各自编码的核酸物质。 本发明还体现了用于扩增所述核酸序列和产生所述突变蛋白的载体和宿主细胞。 还公开了治疗2型糖尿病，肥胖症，代谢综合征以及降低危重病人死亡率和发病率的方法。
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公开(公告)号：US20090118190A1
公开(公告)日：2009-05-07
申请号：US12349119
申请日：2009-01-06
申请人： John Michael Beals , Christopher Carl Frye , Wolfgang Glaesner , Shun Li , Radhakrishnan Rathnachalam , Jing Shang , Beth Ann Strifler , Radmila Micanovic
发明人： John Michael Beals , Christopher Carl Frye , Wolfgang Glaesner , Shun Li , Radhakrishnan Rathnachalam , Jing Shang , Beth Ann Strifler , Radmila Micanovic
摘要： The present invention relates to novel muteins of human fibroblast growth factor 21 with improved pharmaceutical properties. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, metabolic syndrome, and in reducing the mortality and morbidity of critically ill patients.
摘要翻译： 本发明涉及具有改善的药物性质的人成纤维细胞生长因子21的新颖突变蛋白。 公开了蛋白质和各自编码的核酸物质。 本发明还体现了用于扩增所述核酸序列和产生所述突变蛋白的载体和宿主细胞。 还公开了治疗2型糖尿病，肥胖症，代谢综合征以及降低危重病人死亡率和发病率的方法。
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公开(公告)号：US20070142278A1
公开(公告)日：2007-06-21
申请号：US10579510
申请日：2004-12-01
申请人： John Beals , Christopher Frye , Wolfgang Glaesner , Shun Li , Radhakrishnan Rathnachalam , Jing Shang , Beth Strifler , Radmila Micanovic
发明人： John Beals , Christopher Frye , Wolfgang Glaesner , Shun Li , Radhakrishnan Rathnachalam , Jing Shang , Beth Strifler , Radmila Micanovic
摘要： The present invention relates to novel muteins of human fibroblast growth factor 21 with improved pharmaceutical properties. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, metabolic syndrome, and in reducing the mortality and morbidity of critically ill patients.
摘要翻译： 本发明涉及具有改善的药物性质的人成纤维细胞生长因子21的新颖突变蛋白。 公开了蛋白质和各自编码的核酸物质。 本发明还体现了用于扩增所述核酸序列和产生所述突变蛋白的载体和宿主细胞。 还公开了治疗2型糖尿病，肥胖症，代谢综合征以及降低危重病人死亡率和发病率的方法。
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公开(公告)号：US08588226B2
公开(公告)日：2013-11-19
申请号：US12539801
申请日：2009-08-12
申请人： Michael Xie , Jing Shang , Anthony James , Shaohong Wei
发明人： Michael Xie , Jing Shang , Anthony James , Shaohong Wei
CPC分类号： H04L63/0281 , H04L47/20 , H04L63/02 , H04L63/0209
摘要： An integrated security switch and related method for managing connectivity and security among networks. The integrated security switch includes a security function connectable with a first network and at least one switching function connectable with a second network. A common management interface driven by both command line interface and graphic user interface protocols manages the switching function via a management path dedicated between the security function and the switching function. The common management interface enables secure switching of traffic to flow via a traffic path dedicated between the switching function and the security function. Typically, the traffic is a flow of data between the Internet and a group of networked users such as a wide area network.
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