发明授权
- 专利标题： Muteins of human telomerase reverse transcriptase lacking telomerase catalytic activity
- 专利标题（中）： 人端粒酶逆转录酶突变体缺乏端粒酶催化活性
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申请号： US09721477申请日： 2000-11-22
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公开(公告)号： US07517971B1公开(公告)日： 2009-04-14
- 发明人: Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
- 申请人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
- 申请人地址： US CA Menlo Park US CO Boulder
- 专利权人： Geron Corporation,The Regents of the University of Colorado
- 当前专利权人： Geron Corporation,The Regents of the University of Colorado
- 当前专利权人地址： US CA Menlo Park US CO Boulder
- 代理机构： Townsend and Townsend and Crew LLP
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H21/04 ; C12N15/11
摘要：
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.
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