-
公开(公告)号：US07195911B2
公开(公告)日：2007-03-27
申请号：US10044539
申请日：2002-01-11
申请人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
发明人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/1137 , C12N2310/15 , C12N2310/315 , C12N2501/70 , C12N2510/00 , C12Q1/6895 , C12Q2600/156 , C12Q2600/158 , C12Y207/07049
摘要： The present invention is directed to cells comprising a recombinant polynucleotide sequence that encodes a telomerase reverse transcriptase protein, variant, or fragment having telomerase catalytic activity when complexed with a telomerase RNA.
摘要翻译： 本发明涉及包含编码端粒酶逆转录酶蛋白，变体或与端粒酶RNA复合时具有端粒酶催化活性的片段的重组多核苷酸序列的细胞。
-
2.发明授权Methods for detecting nucleic acids encoding human telomerase reverse transcriptase 失效检测编码人端粒酶逆转录酶的核酸的方法公开(公告)号：US07005262B2
公开(公告)日：2006-02-28
申请号：US10054611
申请日：2002-01-18
申请人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
发明人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/1137 , C12N2310/15 , C12N2310/315 , C12Q1/6895 , C12Y207/07049
摘要： The present invention is directed to methods of identifying in a sample nucleic acids that encode human telomerase reverse transcriptase (hTRT) or its fragments. The present invention is also directed to oligonucleotide primers used in such methods. The invention is further directed to PCR products that hybridize under stringent conditions to a polynucleotide encoding hTRT, as well as hybridization complexes comprising one strand of a cellular hTRT nucleic acid and one strand of nucleic acid comprising a recombinant or synthetic fragment of hTRT.
摘要翻译： 本发明涉及鉴定编码人端粒酶逆转录酶（hTRT）或其片段的样品核酸的方法。 本发明还涉及用于这些方法的寡核苷酸引物。 本发明进一步涉及在严格条件下与编码hTRT的多核苷酸杂交的PCR产物，以及包含细胞hTRT核酸的一条链和包含hTRT的重组或合成片段的一条核酸链的杂交复合物。
-
3.发明授权Nucleic acid compositions for eliciting an immune response against telomerase reverse transcriptase 失效用于引发针对端粒酶逆转录酶的免疫应答的核酸组合物公开(公告)号：US07560437B2
公开(公告)日：2009-07-14
申请号：US10044692
申请日：2002-01-11
申请人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
发明人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
IPC分类号： A61K31/7088 , C07H21/02 , C07H21/04
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/1137 , C12N2310/15 , C12N2310/315 , C12N2501/70 , C12N2510/00 , C12Q1/6895 , C12Q2600/156 , C12Q2600/158 , C12Y207/07049
摘要： The present invention is directed to pharmaceutical compositions comprising a telomerase reverse transcriptase polypeptide or a polypeptide homologous to a telomerase reverse transcriptase. The present invention is also directed to pharmaceutical compositions comprising a polynucleotide encoding either of the aforesaid polypeptides. The present invention is further directed to methods for eliciting an immune response to telomerase reverse transcriptase in a subject.
摘要翻译： 本发明涉及包含端粒酶逆转录酶多肽或与端粒酶逆转录酶同源的多肽的药物组合物。 本发明还涉及包含编码上述多肽之一的多核苷酸的药物组合物。 本发明还涉及在受试者中引发对端粒酶逆转录酶的免疫应答的方法。
-
公开(公告)号：US07413864B2
公开(公告)日：2008-08-19
申请号：US10877022
申请日：2004-06-24
申请人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
发明人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
IPC分类号： G01N33/53 , G01N33/567 , G01N33/00 , C12Q1/00
CPC分类号： C12N15/1137 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/113 , C12N2310/15 , C12N2310/315 , C12Q1/6886 , C12Q2600/158 , C12Y207/07049
摘要： The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.
摘要翻译： 本发明提供了与人类端粒酶逆转录酶（hTRT），人端粒酶的催化蛋白质亚基相关的组合物和方法。 本发明的多核苷酸和多肽可用于人类疾病的诊断，预后和治疗，用于改变细胞和生物体的增殖能力，以及用于鉴定和筛选用于治疗诸如癌症的疾病的化合物和治疗。
-
公开(公告)号：US07056513B2
公开(公告)日：2006-06-06
申请号：US09843676
申请日：2001-04-26
申请人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
发明人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/1137 , C12N2310/15 , C12N2310/315 , C12Q1/6895 , C12Y207/07049
摘要： The present invention is directed to novel telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa telomerase protein subunits of Euplotes aediculatus, and related sequences from Schizosaccharomyces, Saccharomyces sequences, and human telomerase. The present invention is also directed to polypeptides comprising these telomerase protein subunits, as well as functional polypeptides and ribonucleoproteins that contain these subunits.
-
公开(公告)号：US06444650B1
公开(公告)日：2002-09-03
申请号：US09052919
申请日：1998-03-31
申请人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
发明人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
IPC分类号： A01N4304
CPC分类号： C12N15/1137 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/113 , C12N2310/15 , C12N2310/315 , C12Y207/07049
摘要： The present invention provides TRT antisense oligonucleotides, methods of detecting TRT, methods of diagnosing telomerase-related conditions, methods of diagnosing and providing a prognosis for cancer, and methods of treating telomerase-related conditions, including cancer.
-
公开(公告)号：US20110318832A1
公开(公告)日：2011-12-29
申请号：US12545774
申请日：2009-08-21
申请人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
发明人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
IPC分类号： C12N5/071
CPC分类号： C12N9/1276 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N9/1241 , C12N15/113 , C12N15/1137 , C12N2310/15 , C12N2310/315 , C12Y207/07049
摘要： The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.
摘要翻译： 本发明提供了与人类端粒酶逆转录酶（hTRT），人端粒酶的催化蛋白质亚基相关的组合物和方法。 本发明的多核苷酸和多肽可用于人类疾病的诊断，预后和治疗，用于改变细胞和生物体的增殖能力，以及用于鉴定和筛选用于治疗诸如癌症的疾病的化合物和治疗。
-
公开(公告)号：US07622549B2
公开(公告)日：2009-11-24
申请号：US10877124
申请日：2004-06-24
申请人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
发明人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
CPC分类号： A61K39/0011 , A01K2217/05 , A61K38/00 , A61K39/0005 , A61K39/39 , A61K48/00 , A61K2039/55505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55544 , A61K2039/55566 , A61K2039/575 , C07K14/43504 , C07K16/40 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/113 , C12N15/1137 , C12N2310/15 , C12N2310/315 , C12Q1/6895 , C12Q2600/156 , C12Q2600/158 , C12Y207/07049
摘要： The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.
摘要翻译： 本发明提供了与人类端粒酶逆转录酶（hTRT），人端粒酶的催化蛋白质亚基相关的组合物和方法。 本发明的多核苷酸和多肽可用于人类疾病的诊断，预后和治疗，用于改变细胞和生物体的增殖能力，以及用于鉴定和筛选用于治疗诸如癌症的疾病的化合物和治疗。
-
9.发明授权Identifying and testing antisense oligonucleotides that inhibit telomerase reverse transcriptase 有权鉴定和测试抑制端粒酶逆转录酶的反义寡核苷酸公开(公告)号：US07297488B2
公开(公告)日：2007-11-20
申请号：US10637443
申请日：2003-08-08
申请人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
发明人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
CPC分类号： C12N15/1137 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/113 , C12N2310/15 , C12N2310/315 , C12Y207/07049
摘要： This disclosure provides TRT antisense oligonucleotides, methods of detecting TRT, methods of diagnosing telomerase-related conditions, methods of diagnosing and providing a prognosis for cancer, and methods of treating telomerase-related conditions, including cancer.
摘要翻译： 本公开提供TRT反义寡核苷酸，检测TRT的方法，诊断端粒酶相关病症的方法，诊断和提供癌症预后的方法，以及治疗端粒酶相关病症（包括癌症）的方法。
-
公开(公告)号：US07285639B2
公开(公告)日：2007-10-23
申请号：US10053758
申请日：2002-01-18
申请人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
发明人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/1137 , C12N2310/15 , C12N2310/315 , C12Q1/6895 , C12Y207/07049
摘要： The present invention is directed to monoclonal or recombinant antibodies or fragments thereof that bind to human telomerase reverse transcriptase (hTRT) protein. The present invention is also directed to methods of identifying or detecting hTRT polypeptides in biological samples. The invention is further directed to methods of generating antibodies that specifically bind to hTRT protein.
摘要翻译： 本发明涉及与人端粒酶逆转录酶（hTRT）蛋白结合的单克隆或重组抗体或其片段。 本发明还涉及在生物样品中鉴定或检测hTRT多肽的方法。 本发明进一步涉及产生特异性结合hTRT蛋白的抗体的方法。
-
-
-
-
-
-
-
-
-
搜索结果
69 条记录 (耗时 0.071 秒)
