发明授权
- 专利标题： Prolinamide derivatives as NK3 antagonists
- 专利标题（中）： 脯氨酰胺衍生物作为NK3拮抗剂
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申请号： US12129718申请日： 2008-05-30
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公开(公告)号： US07528136B2公开(公告)日： 2009-05-05
- 发明人: Bo Han , Henner Knust , Matthias Nettekoven , Hasane Ratni , Xihan Wu
- 申请人： Bo Han , Henner Knust , Matthias Nettekoven , Hasane Ratni , Xihan Wu
- 申请人地址： US NJ Nutley
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- 优先权： EP07109781 20070607
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; A61K31/4725 ; A61K31/401 ; C07D401/06 ; C07D207/16 ; C07D487/10
摘要：
The present invention relates to a compound of formula I wherein R1, R2, R3, R4, R5, X, n, and o are as defined herein and to a pharmaceutically acceptable acid addition salt thereof which are high potential NK-3 receptor antagonists for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).
公开/授权文献
- US20080306086A1 PROLINAMIDE DERIVATIVES AS NK3 ANTAGONISTS 公开/授权日：2008-12-11