发明授权
US07528164B2 Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof
失效
取代的4-芳基-4H-吡咯并[2,3-h]色烯和类似物作为胱天蛋白酶的激活剂和凋亡诱导剂及其用途
![Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof](/docs/US/2009-05-05/US07528164B2/abs.jpg.600x600.jpg)
- 专利标题： Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof
- 专利标题（中）： 取代的4-芳基-4H-吡咯并[2,3-h]色烯和类似物作为胱天蛋白酶的激活剂和凋亡诱导剂及其用途
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申请号： US10514427申请日： 2003-05-16
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公开(公告)号： US07528164B2公开(公告)日： 2009-05-05
- 发明人: Sui Xiong Cai , Songchun Jiang , William E. Kemnitzer , Hong Zhang , Giorgio Attardo , Real Denis
- 申请人： Sui Xiong Cai , Songchun Jiang , William E. Kemnitzer , Hong Zhang , Giorgio Attardo , Real Denis
- 申请人地址： US CA San Diego CA Quebec
- 专利权人： Cytovia, Inc.,Shire BioChem, Inc.
- 当前专利权人： Cytovia, Inc.,Shire BioChem, Inc.
- 当前专利权人地址： US CA San Diego CA Quebec
- 代理机构： Sterne, Kessler, Goldstein & Fox, P.L.L.C.
- 国际申请： PCT/US03/15427 WO 20030516
- 国际公布： WO03/097806 WO 20031127
- 主分类号： A61K31/407
- IPC分类号： A61K31/407
![Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof](/abs-image/US/2009/05/05/US07528164B2/abs.jpg.150x150.jpg)
摘要：
The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the Formula (I): wherein R1, R3-R5, A, D, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.