发明授权
US07534863B2 Leucine-based motifs and enhanced biological persistence of clostridial neurotoxins
有权
基于亮氨酸的图案和增强的梭菌神经毒素的生物持续性
- 专利标题： Leucine-based motifs and enhanced biological persistence of clostridial neurotoxins
- 专利标题（中）： 基于亮氨酸的图案和增强的梭菌神经毒素的生物持续性
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申请号： US10753537申请日： 2004-01-08
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公开(公告)号： US07534863B2公开(公告)日： 2009-05-19
- 发明人: Lance E. Steward , Ester Fernandez-Salas , Todd M. Herrington , Kei Roger Aoki
- 申请人： Lance E. Steward , Ester Fernandez-Salas , Todd M. Herrington , Kei Roger Aoki
- 申请人地址： US CA Irvine
- 专利权人： Allergan, Inc.
- 当前专利权人： Allergan, Inc.
- 当前专利权人地址： US CA Irvine
- 代理商 Dean G. Stathakis; Joel B. German; Debra D. Condino
- 主分类号： C07K14/33
- IPC分类号： C07K14/33
摘要：
Modified neurotoxin comprising neurotoxin including structural modification, wherein the structural modification alters the biological persistence, such as the biological half-life and/or a biological activity of the modified neurotoxin relative to an identical neurotoxin without the structural modification. In one embodiment, methods of making the modified neurotoxin include using recombinant techniques. In another embodiment, methods of using the modified neurotoxin to treat conditions include treating various disorders, neuromuscular aliments and pain.
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