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公开(公告)号：US07691974B2
公开(公告)日：2010-04-06
申请号：US12054667
申请日：2008-03-25
IPC分类号： C07K14/33
CPC分类号： C07K14/33 , A61K38/00 , Y10S530/825
摘要： Modified neurotoxin comprising neurotoxin including structural modification, wherein the structural modification alters the biological persistence, preferably the biological half-life, of the modified neurotoxin relative to an identical neurotoxin without the structural modification. The structural modification includes addition or deletion of a leucine-based motif or parts thereof. In one embodiment, methods of making the modified neurotoxin include using recombinant techniques. In another embodiment, methods of using the modified neurotoxin to treat biological disorders include treating autonomic disorders, neuromuscular disorders or pains.
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公开(公告)号：US07491799B2
公开(公告)日：2009-02-17
申请号：US10757077
申请日：2004-01-14
IPC分类号： C07K14/33
CPC分类号： C07K14/33 , A61K38/00 , C07K2319/01
摘要： Natural and modified neurotoxins and isolated neurotoxin compositions are described. The neurotoxins may include one or more structural modifications, wherein the structural modification(s) alters the biological persistence, such as the biological half-life and/or a biological activity of the modified neurotoxin relative to an identical neurotoxin without the structural modification(s). In one embodiment, methods of making the modified neurotoxin include using recombinant techniques. In some embodiments, methods of using the modified neurotoxin to treat conditions include treating various disorders, neuromuscular ailments and pain.
摘要翻译： 描述了天然和修饰的神经毒素和分离的神经毒素组合物。 神经毒素可以包括一种或多种结构修饰，其中结构修饰改变了相对于相同的神经毒素而没有结构修饰的生物学持久性，例如修饰的神经毒素的生物半衰期和/或生物活性 ）。 在一个实施方案中，制备修饰的神经毒素的方法包括使用重组技术。 在一些实施方案中，使用经修饰的神经毒素治疗病症的方法包括治疗各种疾病，神经肌肉疾病和疼痛。
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公开(公告)号：US20080194797A1
公开(公告)日：2008-08-14
申请号：US12056459
申请日：2008-03-27
IPC分类号： C07K14/33
CPC分类号： C07K14/33 , A61K38/00 , Y10S530/825
摘要： Modified neurotoxin comprising neurotoxin including structural modification, wherein the structural modification alters the biological persistence, preferably the biological half-life, of the modified neurotoxin relative to an identical neurotoxin without the structural modification. The structural modification includes addition or deletion of a leucine-based motif or parts thereof. In one embodiment, methods of making the modified neurotoxin include using recombinant techniques. In another embodiment, methods of using the modified neurotoxin to treat biological disorders include treating autonomic disorders, neuromuscular disorders or pains.
摘要翻译： 包含神经毒素的改性神经毒素包括结构修饰，其中所述结构修饰改变了修饰神经毒素相对于相同神经毒素的生物学持续性，优选生物半衰期而没有结构修饰。 结构修饰包括加入或缺失基于亮氨酸的基序或其部分。 在一个实施方案中，制备修饰的神经毒素的方法包括使用重组技术。 在另一个实施方案中，使用经修饰的神经毒素治疗生物学障碍的方法包括治疗自主神经障碍，神经肌肉疾病或疼痛。
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公开(公告)号：US06903187B1
公开(公告)日：2005-06-07
申请号：US09620840
申请日：2000-07-21
IPC分类号： C12N15/09 , A61K38/00 , A61P1/00 , A61P5/00 , A61P21/00 , A61P25/00 , A61P25/04 , A61P27/02 , A61P29/02 , A61P37/00 , C07K14/33
CPC分类号： C07K14/33 , A61K38/00 , Y10S530/825
摘要： Modified neurotoxin comprising neurotoxin including structural modification, wherein the structural modification alters the biological persistence, preferably the biological half-life, of the modified neurotoxin relative to an identical neurotoxin without the structural modification. The structural modification includes addition or deletion of a leucine-based motif or parts thereof. In one embodiment, methods of making the modified neurotoxin include using recombinant techniques. In another embodiment, methods of using the modified neurotoxin to treat biological disorders include treating autonomic disorders, neuromuscular disorders or pains.
摘要翻译： 包含神经毒素的改性神经毒素包括结构修饰，其中所述结构修饰改变了修饰神经毒素相对于相同神经毒素的生物学持续性，优选生物半衰期而没有结构修饰。 结构修饰包括加入或缺失基于亮氨酸的基序或其部分。 在一个实施方案中，制备修饰的神经毒素的方法包括使用重组技术。 在另一个实施方案中，使用经修饰的神经毒素治疗生物学障碍的方法包括治疗自主神经障碍，神经肌肉疾病或疼痛。
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公开(公告)号：US08206723B2
公开(公告)日：2012-06-26
申请号：US12416470
申请日：2009-04-01
IPC分类号： C07K14/33
CPC分类号： C07K14/33 , A61K38/00 , Y10S530/825
摘要： Modified neurotoxin comprising neurotoxin including structural modification, wherein the structural modification alters the biological persistence, such as the biological half-life and/or a biological activity of the modified neurotoxin relative to an identical neurotoxin without the structural modification. In one embodiment, methods of making the modified neurotoxin include using recombinant techniques. In another embodiment, methods of using the modified neurotoxin to treat conditions include treating various disorders, neuromuscular aliments and pain.
摘要翻译： 包含神经毒素的改性神经毒素包括结构修饰，其中所述结构修饰改变了相对于相同的神经毒素而没有结构修饰的生物学持久性，例如修饰的神经毒素的生物半衰期和/或生物活性。 在一个实施方案中，制备修饰的神经毒素的方法包括使用重组技术。 在另一个实施方案中，使用经修饰的神经毒素治疗病症的方法包括治疗各种疾病，神经肌肉营养和疼痛。
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公开(公告)号：US20080177037A1
公开(公告)日：2008-07-24
申请号：US12053998
申请日：2008-03-24
IPC分类号： C07K7/00
CPC分类号： C07K14/33 , A61K38/00 , Y10S530/825
摘要： Modified neurotoxin comprising neurotoxin including structural modification, wherein the structural modification alters the biological persistence, preferably the biological half-life, of the modified neurotoxin relative to an identical neurotoxin without the structural modification. The structural modification includes addition or deletion of a leucine-based motif or parts thereof. In one embodiment, methods of making the modified neurotoxin include using recombinant techniques. In another embodiment, methods of using the modified neurotoxin to treat biological disorders include treating autonomic disorders, neuromuscular disorders or pains.
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公开(公告)号：US07671177B2
公开(公告)日：2010-03-02
申请号：US12057642
申请日：2008-03-28
IPC分类号： C07K14/33
CPC分类号： C07K14/33 , A61K38/00 , Y10S530/825
摘要： Modified neurotoxin comprising neurotoxin including structural modification, wherein the structural modification alters the biological persistence, preferably the biological half-life, of the modified neurotoxin relative to an identical neurotoxin without the structural modification. The structural modification includes addition or deletion of a leucine-based motif or parts thereof. In one embodiment, methods of making the modified neurotoxin include using recombinant techniques. In another embodiment, methods of using the modified neurotoxin to treat biological disorders include treating autonomic disorders, neuromuscular disorders or pains.
摘要翻译： 包含神经毒素的改性神经毒素包括结构修饰，其中所述结构修饰改变了修饰神经毒素相对于相同神经毒素的生物学持续性，优选生物半衰期而没有结构修饰。 结构修饰包括加入或缺失基于亮氨酸的基序或其部分。 在一个实施方案中，制备修饰的神经毒素的方法包括使用重组技术。 在另一个实施方案中，使用经修饰的神经毒素治疗生物学障碍的方法包括治疗自主神经障碍，神经肌肉疾病或疼痛。
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公开(公告)号：US20090202591A1
公开(公告)日：2009-08-13
申请号：US12416470
申请日：2009-04-01
CPC分类号： C07K14/33 , A61K38/00 , Y10S530/825
摘要： Modified neurotoxin comprising neurotoxin including structural modification, wherein the structural modification alters the biological persistence, such as the biological half-life and/or a biological activity of the modified neurotoxin relative to an identical neurotoxin without the structural modification. In one embodiment, methods of making the modified neurotoxin include using recombinant techniques. In another embodiment, methods of using the modified neurotoxin to treat conditions include treating various disorders, neuromuscular aliments and pain.
摘要翻译： 包含神经毒素的改性神经毒素包括结构修饰，其中所述结构修饰改变了相对于相同的神经毒素而没有结构修饰的生物学持久性，例如修饰的神经毒素的生物半衰期和/或生物活性。 在一个实施方案中，制备修饰的神经毒素的方法包括使用重组技术。 在另一个实施方案中，使用经修饰的神经毒素治疗病症的方法包括治疗各种疾病，神经肌肉营养和疼痛。
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9.发明授权Leucine-based motifs and enhanced biological persistence of clostridial neurotoxins 有权基于亮氨酸的图案和增强的梭菌神经毒素的生物持续性公开(公告)号：US07534863B2
公开(公告)日：2009-05-19
申请号：US10753537
申请日：2004-01-08
IPC分类号： C07K14/33
CPC分类号： C07K14/33 , A61K38/00 , Y10S530/825
摘要： Modified neurotoxin comprising neurotoxin including structural modification, wherein the structural modification alters the biological persistence, such as the biological half-life and/or a biological activity of the modified neurotoxin relative to an identical neurotoxin without the structural modification. In one embodiment, methods of making the modified neurotoxin include using recombinant techniques. In another embodiment, methods of using the modified neurotoxin to treat conditions include treating various disorders, neuromuscular aliments and pain.
摘要翻译： 包含神经毒素的改性神经毒素包括结构修饰，其中所述结构修饰改变了相对于相同的神经毒素而没有结构修饰的生物学持久性，例如修饰的神经毒素的生物半衰期和/或生物活性。 在一个实施方案中，制备修饰的神经毒素的方法包括使用重组技术。 在另一个实施方案中，使用经修饰的神经毒素治疗病症的方法包括治疗各种疾病，神经肌肉营养和疼痛。
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公开(公告)号：US20080214781A1
公开(公告)日：2008-09-04
申请号：US12054667
申请日：2008-03-25
IPC分类号： C07K2/00
CPC分类号： C07K14/33 , A61K38/00 , Y10S530/825
摘要： Modified neurotoxin comprising neurotoxin including structural modification, wherein the structural modification alters the biological persistence, preferably the biological half-life, of the modified neurotoxin relative to an identical neurotoxin without the structural modification. The structural modification includes addition or deletion of a leucine-based motif or parts thereof. In one embodiment, methods of making the modified neurotoxin include using recombinant techniques. In another embodiment, methods of using the modified neurotoxin to treat biological disorders include treating autonomic disorders, neuromuscular disorders or pains.
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