Invention Grant
US07558717B2 Crystal structure of human JAK3 kinase domain complex and binding pockets thereof
失效
人类JAK3激酶结构域复合物的晶体结构及其结合口袋
- Patent Title: Crystal structure of human JAK3 kinase domain complex and binding pockets thereof
- Patent Title (中): 人类JAK3激酶结构域复合物的晶体结构及其结合口袋
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Application No.: US11114979Application Date: 2005-04-26
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Publication No.: US07558717B2Publication Date: 2009-07-07
- Inventor: Harmon Zuccola , Marc Jacobs , Lovorka Swenson , Kumkum Saxena
- Applicant: Harmon Zuccola , Marc Jacobs , Lovorka Swenson , Kumkum Saxena
- Applicant Address: US MA Cambridge
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Cambridge
- Agency: Ropes & Gray LLP
- Agent James F. Haley, Jr.; Raymond M. Doss
- Main IPC: C12Q1/00
- IPC: C12Q1/00 ; C12Q1/48 ; G01N33/53 ; G01N31/00 ; C12N9/00 ; C12N9/12 ; G06G7/58
Abstract:
The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to JAK3 protein or JAK3 protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising JAK3 kinase domain and JAK3 kinase domain complexed with AMP-PNP.
Public/Granted literature
- US20060030018A1 Crystal structure of human JAK3 kinase domain complex and binding pockets thereof Public/Granted day:2006-02-09
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