发明授权
- 专利标题： Antibodies to human vascular endothelial growth factor 2 and methods of using the same
- 专利标题（中）： 人血管内皮生长因子2的抗体及其使用方法
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申请号： US11211724申请日： 2005-08-26
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公开(公告)号： US07576189B2公开(公告)日： 2009-08-18
- 发明人: Craig A. Rosen , Jing-Shan Hu , Liang Cao
- 申请人： Craig A. Rosen , Jing-Shan Hu , Liang Cao
- 申请人地址： US MD Rockville
- 专利权人： Human Genome Sciences, Inc.
- 当前专利权人： Human Genome Sciences, Inc.
- 当前专利权人地址： US MD Rockville
- 代理机构： Sterne, Kessler, Goldstein & Fox P.L.L.C.
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; C12P21/08 ; G01N33/53 ; A61K39/395 ; A61K39/00
摘要：
Disclosed is a human VEGF2 polypeptide and DNA(RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Also disclosed is a method of using such polypeptide for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antagonists to inhibit tumor growth, inflammation and to treat diabetic retinopathy, rheumatoid arthritis and psoriasis. Diagnostic methods for detecting mutations in the VEGF2 coding sequence and alterations in the concentration of VEGF2 protein in a sample derived from a host are also disclosed.
公开/授权文献
- US20050287143A1 Human vascular endothelial growth factor 2 公开/授权日：2005-12-29
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