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公开(公告)号：US20100143360A1
公开(公告)日：2010-06-10
申请号：US12258109
申请日：2008-10-24
Applicant: Craig Rosen , Jing-Shan Hu , Liang Cao
Inventor： Craig Rosen , Jing-Shan Hu , Liang Cao
IPC: A61K39/395 , G01N33/53 , C12N9/96 , C12N5/16 , C07K16/00
CPC classification number: C07K14/52 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/026
Abstract: Disclosed is a human VEGF2 polypeptide and DNA(RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Also disclosed is a method of using such polypeptide for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antagonists to inhibit tumor growth, inflammation and to treat diabetic retinopathy, rheumatoid arthritis and psoriasis. Diagnostic methods for detecting mutations in the VEGF2 coding sequence and alterations in the concentration of VEGF2 protein in a sample derived from a host are also disclosed.
Abstract translation: 公开了编码这种VEGF2多肽的人VEGF2多肽和DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还公开了使用这种多肽刺激伤口愈合和维持血管组织修复的方法。 还提供了使用拮抗剂抑制肿瘤生长，炎症和治疗糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。 还公开了用于检测VEGF2编码序列中的突变和来自宿主的样品中VEGF2蛋白浓度变化的诊断方法。
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公开(公告)号：US20070154912A1
公开(公告)日：2007-07-05
申请号：US11566261
申请日：2006-12-04
Applicant: Paul Young , John Greene , Ann Ferrie , Steven Ruben , Craig Rosen , Roxanne Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Paul Moore , Yanggu Shi , David LaFleur , Jian Ni
Inventor： Paul Young , John Greene , Ann Ferrie , Steven Ruben , Craig Rosen , Roxanne Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Paul Moore , Yanggu Shi , David LaFleur , Jian Ni
CPC classification number: C12Q1/6883 , A61K38/00 , C07K14/47 , G01N33/6893
Abstract: The present invention relates to 87 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
Abstract translation: 本发明涉及87种新的人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US07227005B1
公开(公告)日：2007-06-05
申请号：US09257272
申请日：1999-02-25
Applicant: Jing-Shan Hu , Craig A. Rosen , Liang Cao
Inventor： Jing-Shan Hu , Craig A. Rosen , Liang Cao
CPC classification number: C07K14/52 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/026
Abstract: Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.
Abstract translation: 公开了人VEGF2多肽，生物活性，诊断学或治疗上有用的片段，类似物或衍生物，以及编码这种VEGF2多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。 还提供了使用抗体和拮抗剂抑制肿瘤血管发生，从而抑制肿瘤生长，炎症，糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。
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公开(公告)号：US20060223077A1
公开(公告)日：2006-10-05
申请号：US11229770
申请日：2005-09-20
Applicant: Jian Ni , Reinhard Ebner , David LaFleur , Paul Moore , Henrik Olsen , Craig Rosen , Steven Ruben , Daniel Soppet , Paul Young , Yanggu Shi , Kimberly Florence , Ying-Fei Wei , Charles Florence , Jing-Shan Hu , Yi Li , Hla Kyaw , Carrie Fischer , Ann Ferrie , Ping Fan , Ping Feng , Gregory Endress , Patrick Dillon , Kenneth Carter , Laurie Brewer , Guo-Liang Yu , Zhizhen Zeng , John Greene
Inventor： Jian Ni , Reinhard Ebner , David LaFleur , Paul Moore , Henrik Olsen , Craig Rosen , Steven Ruben , Daniel Soppet , Paul Young , Yanggu Shi , Kimberly Florence , Ying-Fei Wei , Charles Florence , Jing-Shan Hu , Yi Li , Hla Kyaw , Carrie Fischer , Ann Ferrie , Ping Fan , Ping Feng , Gregory Endress , Patrick Dillon , Kenneth Carter , Laurie Brewer , Guo-Liang Yu , Zhizhen Zeng , John Greene
Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
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公开(公告)号：US6040157A
公开(公告)日：2000-03-21
申请号：US42105
申请日：1998-03-13
Applicant: Jing-Shan Hu , Craig A. Rosen , Liang Cao
Inventor： Jing-Shan Hu , Craig A. Rosen , Liang Cao
CPC classification number: C07K14/52 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/026
Abstract: Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeuticall sefl fragments, analogs, or derivatives thereof, and DNA (RNA) enco such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.
Abstract translation: 公开了人类VEGF2多肽，生物学活性，诊断学或治疗学的sefl片段，类似物或其衍生物，和遇到这种VEGF2多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。 还提供了使用抗体和拮抗剂抑制肿瘤血管发生，从而抑制肿瘤生长，炎症，糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。
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Patent Agency Ranking
6.发明授权Antibodies to human vascular endothelial growth factor 2 and methods of using the same 失效人血管内皮生长因子2的抗体及其使用方法公开(公告)号：US07576189B2
公开(公告)日：2009-08-18
申请号：US11211724
申请日：2005-08-26
Applicant: Craig A. Rosen , Jing-Shan Hu , Liang Cao
Inventor： Craig A. Rosen , Jing-Shan Hu , Liang Cao
IPC: C07K16/00 , C12P21/08 , G01N33/53 , A61K39/395 , A61K39/00
CPC classification number: G01N33/68 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/52 , C07K2319/00 , C12N2799/026 , G01N2333/515
Abstract: Disclosed is a human VEGF2 polypeptide and DNA(RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Also disclosed is a method of using such polypeptide for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antagonists to inhibit tumor growth, inflammation and to treat diabetic retinopathy, rheumatoid arthritis and psoriasis. Diagnostic methods for detecting mutations in the VEGF2 coding sequence and alterations in the concentration of VEGF2 protein in a sample derived from a host are also disclosed.
Abstract translation: 公开了编码这种VEGF2多肽的人VEGF2多肽和DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还公开了使用这种多肽刺激伤口愈合和维持血管组织修复的方法。 还提供了使用拮抗剂抑制肿瘤生长，炎症和治疗糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。 还公开了用于检测VEGF2编码序列中的突变和来自宿主的样品中VEGF2蛋白浓度变化的诊断方法。
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公开(公告)号：US20090197278A9
公开(公告)日：2009-08-06
申请号：US12036846
申请日：2008-02-25
Applicant: Paul A. Moore , Reiner L. Gentz , Henry Hongjun Ji , Jian Ni , Jing-Shan Hu , Craig A. Rosen
Inventor： Paul A. Moore , Reiner L. Gentz , Henry Hongjun Ji , Jian Ni , Jing-Shan Hu , Craig A. Rosen
Abstract: Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.
Abstract translation: 公开了编码此类多肽的人多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了将这些多肽用于治疗目的的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗剂的用途。 还公开了用于检测利用序列和多肽的疾病的诊断方法。
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公开(公告)号：US20080227110A1
公开(公告)日：2008-09-18
申请号：US12036846
申请日：2008-02-25
Applicant: Paul A. Moore , Reiner L. Gentz , Henry Hongjun Ji , Jian Ni , Jing-Shan Hu , Craig A. Rosen
Inventor： Paul A. Moore , Reiner L. Gentz , Henry Hongjun Ji , Jian Ni , Jing-Shan Hu , Craig A. Rosen
Abstract: Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.
Abstract translation: 公开了编码这种多肽的人多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了将这些多肽用于治疗目的的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗剂的用途。 还公开了用于检测利用序列和多肽的疾病的诊断方法。
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9.发明授权Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2 失效通过施用血管内皮生长因子2刺激患者血管生成的方法公开(公告)号：US07186688B1
公开(公告)日：2007-03-06
申请号：US09107997
申请日：1998-06-30
Applicant: Jing-Shan Hu , Craig A. Rosen , Liang Cao
Inventor： Jing-Shan Hu , Craig A. Rosen , Liang Cao
CPC classification number: A61K38/1866 , A61K38/179 , A61K2039/505 , C07K16/22
Abstract: Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA (RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.
Abstract translation: 公开了人VEGF2多肽，生物活性，诊断学或治疗上有用的片段，类似物或衍生物，以及编码这种VEGF2多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。 还提供了使用抗体和拮抗剂抑制肿瘤血管发生，从而抑制肿瘤生长，炎症，糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。
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公开(公告)号：US07109308B1
公开(公告)日：2006-09-19
申请号：US10023584
申请日：2001-12-21
Applicant: Craig A. Rosen , Jing-Shan Hu , Liang Cao
Inventor： Craig A. Rosen , Jing-Shan Hu , Liang Cao
CPC classification number: G01N33/68 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/52 , C07K2319/00 , C12N2799/026 , G01N2333/515
Abstract: Disclosed is a human VEGF2 polypeptide and DNA(RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Also disclosed is a method of using such polypeptide for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antagonists to inhibit tumor growth, inflammation and to treat diabetic retinopathy, rheumatoid arthritis and psoriasis. Diagnostic methods for detecting mutations in the VEGF2 coding sequence and alterations in the concentration of VEGF2 protein in a sample derived from a host are also disclosed.
Abstract translation: 公开了编码这种VEGF2多肽的人VEGF2多肽和DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还公开了使用这种多肽刺激伤口愈合和维持血管组织修复的方法。 还提供了使用拮抗剂抑制肿瘤生长，炎症和治疗糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。 还公开了用于检测VEGF2编码序列中的突变和来自宿主的样品中VEGF2蛋白浓度变化的诊断方法。
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