- 专利标题： Analogs of benzoquinone-containing ansamycins and methods of use thereof
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申请号： US12199415申请日： 2008-08-27
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公开(公告)号： US07579337B2公开(公告)日： 2009-08-25
- 发明人: Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
- 申请人： Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
- 申请人地址： US MA Cambridge
- 专利权人： Infinity Pharmaceuticals, Inc.
- 当前专利权人： Infinity Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Foley Hoag LLP
- 主分类号： C07D225/06
- IPC分类号： C07D225/06 ; A61K31/395 ; A61P35/00
摘要：
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
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