Invention Grant
US07589117B2 Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them
有权
异吲哚酮衍生物，该方法的制备方法和中间体，它们作为药物的用途，以及包含它们的药物组合物
- Patent Title: Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them
- Patent Title (中): 异吲哚酮衍生物，该方法的制备方法和中间体，它们作为药物的用途，以及包含它们的药物组合物
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Application No.: US11365319Application Date: 2006-03-01
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Publication No.: US07589117B2Publication Date: 2009-09-15
- Inventor: Heinz-Werner Kleemann , Armin Hofmeister , Jean-Christophe Carry , Baptiste Ronan , Serge Mignani , Antony Bigot
- Applicant: Heinz-Werner Kleemann , Armin Hofmeister , Jean-Christophe Carry , Baptiste Ronan , Serge Mignani , Antony Bigot
- Applicant Address: DE Frankfurt
- Assignee: sanofi-aventis Deutschland GmbH
- Current Assignee: sanofi-aventis Deutschland GmbH
- Current Assignee Address: DE Frankfurt
- Agent Raymond S. Parker; James W. Bolcsak
- Priority: FR0206783 20020603
- Main IPC: A61K31/40
- IPC: A61K31/40
Abstract:
The present invention relates to the novel isoindolone derivatives of the formula I in which R1 to R6 have the meanings stated in the claims. The inventive compounds are suitable as antiarrhythmic medicaments with a cardioprotective component for infarction prophylaxis and infarction treatment and for the treatment of angina pectoris. They also inhibit in a preventive manner the pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure.
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