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公开(公告)号：US08748614B2
公开(公告)日：2014-06-10
申请号：US12487455
申请日：2009-06-18
IPC分类号： A61K31/535 , C07D217/00
CPC分类号： C07D401/12 , C07D401/14 , C07D409/14
摘要： The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异诺酮酮衍生物， 化合物。
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公开(公告)号：US08710228B2
公开(公告)日：2014-04-29
申请号：US12487386
申请日：2009-06-18
申请人： Oliver Plettenburg , Armin Hofmeister , Dieter Kadereit , Stefan Peukert , Sven Ruf , Matthias Löhn , Peter Monecke , Alexander Schiffer , Aimo Kannt , Markus Kohlmann
发明人： Oliver Plettenburg , Armin Hofmeister , Dieter Kadereit , Stefan Peukert , Sven Ruf , Matthias Löhn , Peter Monecke , Alexander Schiffer , Aimo Kannt , Markus Kohlmann
IPC分类号： A61K31/47 , C07D217/00
CPC分类号： C07D217/24 , C07D401/04 , C07D401/12 , C07D401/14
摘要： The invention relates to 6-substituted isoquinoline derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代的异喹啉衍生物和含有这些化合物的组合物。
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3.发明授权N-substituted (benzoimidazol-2-yl)phenylamines, processes for their preparation, their use as a medicament or diagnostic aid, and a medicament comprising them 失效N-取代的（苯并咪唑-2-基）苯胺，其制备方法，它们作为药物或诊断助剂的用途，以及包含它们的药物公开(公告)号：US08067614B2
公开(公告)日：2011-11-29
申请号：US12722634
申请日：2010-03-12
申请人： Uwe Heinelt , Hans-Jochen Lang , Armin Hofmeister , Klaus Wirth , Martin Hug
发明人： Uwe Heinelt , Hans-Jochen Lang , Armin Hofmeister , Klaus Wirth , Martin Hug
IPC分类号： A61K31/4184 , C07D235/30
CPC分类号： C07D235/30
摘要： This invention is directed to the compound of formula (I), compositions containing said compounds to inhibit the sodium-proton exchanger of subtype 3 (NHE3) which are useful in the prevention or treatment of various disorders in a patient suffering from a disease state, such as, renal disorders including acute or chronic renal failure, disorders of biliary function and for respiratory disorders such as snoring or sleep apnea or for stroke.
摘要翻译： 本发明涉及式（I）化合物，含有抑制亚型3（NHE3）的钠 - 质子交换剂的所述化合物的组合物，其可用于预防或治疗患有疾病状态的患者中的各种疾病， 例如包括急性或慢性肾衰竭，胆汁功能障碍和呼吸系统疾病如打鼾或睡眠呼吸暂停或中风的肾脏疾病。
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4.发明申请SUBSTITUTED TETRAHYDRO-2H-ISOQUINOLIN-1-ONE DERIVATIVES, AND METHODS FOR THE PRODUCTION AND USE THEREOF 审中-公开取代的四氢-2H-异喹啉-1-酮衍生物及其生产和使用方法公开(公告)号：US20110021462A1
公开(公告)日：2011-01-27
申请号：US12850328
申请日：2010-08-04
IPC分类号： A61K31/69 , A61K31/472 , A61K31/4725 , A61P9/10 , A61P19/02 , A61P9/00 , A61P25/28 , A61P27/02 , A61P43/00 , A61P25/00 , A61P35/00 , A61P3/10 , A61P21/00
CPC分类号： C07D413/14 , C07D217/24 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/14
摘要： This invention relates to compounds according to the general formula (I), where the definitions of the substituents R1, R2, Ar and X are as specified in the description, and to their physiologically tolerated salts, methods for the preparation of these compounds and their use as medicaments. These compounds are poly(ADP-ribose) polymerase (PARP) inhibitors.
摘要翻译： 本发明涉及根据通式（I）的化合物，其中取代基R 1，R 2，Ar和X的定义如说明书中所述，及其生理上可耐受的盐，制备这些化合物的方法及其制备方法 用作药物。 这些化合物是聚（ADP-核糖）聚合酶（PARP）抑制剂。
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5.发明授权Substituted tetrahydro-2H-isoquinolin-1-one derivatives, and methods for the production and use thereof 失效取代的四氢-2H-异喹啉-1-酮衍生物及其制备和使用方法公开(公告)号：US07795278B2
公开(公告)日：2010-09-14
申请号：US11567352
申请日：2006-12-06
IPC分类号： C07D217/22 , A61K31/47
CPC分类号： C07D413/14 , C07D217/24 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/14
摘要： This invention relates to compounds according to the general formula (I), where the definitions of the substituents R1, R2, Ar and X are as specified in the description, and to their physiologically tolerated salts, methods for the preparation of these compounds and their use as medicaments. These compounds are poly(ADP-ribose) polymerase (PARP) inhibitors.
摘要翻译： 本发明涉及根据通式（I）的化合物，其中取代基R 1，R 2，Ar和X的定义如说明书中所述，及其生理上可耐受的盐，制备这些化合物的方法及其制备方法 用作药物。 这些化合物是聚（ADP-核糖）聚合酶（PARP）抑制剂。
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公开(公告)号：US20100105650A1
公开(公告)日：2010-04-29
申请号：US12487455
申请日：2009-06-18
IPC分类号： A61K31/4725 , C07D401/12 , C07D401/14 , A61K31/55 , A61P9/12 , A61P27/02 , A61P9/00
CPC分类号： C07D401/12 , C07D401/14 , C07D409/14
摘要： The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异诺酮酮衍生物， 化合物。
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7.发明授权Substituted 2-aminoimidazoles, process for their preparation, their use as medicament or diagnostic aid 失效取代的2-氨基咪唑，其制备方法，用作药物或诊断辅助剂公开(公告)号：US07442717B2
公开(公告)日：2008-10-28
申请号：US10771185
申请日：2004-02-03
IPC分类号： A61K31/4168 , C07D233/88
CPC分类号： C07D233/50
摘要： Novel substituted 2-aminoimidazoles of formula I, process for their preparation, their use as medicament or diagnostic aid, and medicament containing them. The compounds of this type are useful in the prevention or treatment of various disorders and can be employed inter alia for renal disorders such as acute or chronic renal failure, for disorders of biliary function, for respiratory disorders such as snoring or sleep apneas or for stroke
摘要翻译： 式I的新型取代的2-氨基咪唑，其制备方法，它们作为药物或诊断助剂的用途以及含有它们的药物。 这种类型的化合物可用于预防或治疗各种疾病，并且可以特别用于肾脏疾病如急性或慢性肾衰竭，胆汁功能障碍，呼吸障碍如打鼾或睡眠呼吸暂停或中风
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8.发明申请SUBSTITUTED TETRAHYDROISOCHINOLINES AS MMP INHIBITORS, RELATED PRODUCTION METHOD AND USE AS MEDICINE 有权作为基质金属蛋白酶抑制剂的相关生产方法和作为药物使用的取代的四氢吲哚公开(公告)号：US20080090821A1
公开(公告)日：2008-04-17
申请号：US11862818
申请日：2007-09-27
IPC分类号： A61K31/472 , A61K31/496 , A61K31/5377 , A61P19/00 , A61P29/00 , A61P35/00 , A61P9/00 , C07D401/02 , C07D413/02
CPC分类号： C07D217/26 , C07D403/12
摘要： The present invention is directed to a compound of formula (1), wherein R1, R2, R3, R4, A, L and n are as defined herein, its pharmaceutical composition, preparation and uses as a MMP inhibitor.
摘要翻译： 本发明涉及式（1）的化合物，其中R 1，R 2，R 3，R 4 A，L和n如本文所定义，其药物组合物，制剂和用作MMP抑制剂。
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9.发明授权公开(公告)号：US07205315B2
公开(公告)日：2007-04-17
申请号：US10950802
申请日：2004-09-27
申请人： Manfred Schudok , Hans Matter , Armin Hofmeister
发明人： Manfred Schudok , Hans Matter , Armin Hofmeister
IPC分类号： A61K31/4725 , C07D217/22 , C07D217/24
CPC分类号： C07D217/26 , C07D405/12
摘要： The present invention is directed to a compound of formula (I), or a stereoisomer or a mixture of stereoisomer thereof in any ratio, or its physiologically tolerable salt, which is useful as an inhibitor of matrix metalloproteinase. The present invention is also directed to a pharmaceutical preparation comprising a pharmaceutically effective amount of at least one compound of formula (I); processes for their preparation; the use of a compound of formula (I) having activity as an matrix metalloproteinase inhibitor; and for the prophylaxis and therapy of disease states that involve an increase in the activity of matrix metalloproteinase.
摘要翻译： 本发明涉及式（I）化合物或其任何比例的立体异构体或其立体异构体的混合物或其生理上可耐受的盐，其可用作基质金属蛋白酶的抑制剂。 本发明还涉及包含药学有效量的至少一种式（I）化合物的药物制剂; 其准备过程; 使用具有活性的式（I）化合物作为基质金属蛋白酶抑制剂; 以及用于预防和治疗涉及基质金属蛋白酶活性增加的疾病状态。
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10.发明授权Substituted benzimidazoles, processes for their preparation, their use as medicaments, and medicaments comprising them 失效取代的苯并咪唑，其制备方法，它们作为药物的用途，以及包含它们的药物公开(公告)号：US06686384B2
公开(公告)日：2004-02-03
申请号：US10000028
申请日：2001-12-04
申请人： Armin Hofmeister , Uwe Heinelt , Hans-Jochen Lang , Markus Bleich , Klaus Wirth , Michael Gekle
发明人： Armin Hofmeister , Uwe Heinelt , Hans-Jochen Lang , Markus Bleich , Klaus Wirth , Michael Gekle
IPC分类号： A61K314184
CPC分类号： C07D235/30
摘要： The invention relates to the use of compounds of formula I for the production of a medicament for the treatment of illnesses which can be influenced by inhibition of the Na+/H+ exchanger, and to a medicament comprising them: in which R1 to R9 have the meanings shown in the claims.
摘要翻译： 本发明涉及式I化合物用于制备可受Na + / H +交换剂的抑制影响的疾病的药物的用途，以及包含它们的药物的用途：其中R 1至R 9具有以下含义： 如权利要求中所示。
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