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1.发明授权1,2,3,4-tetrahydro-pyrimido(1,2-a)pyrimidin-6-one derivatives, preparation thereof, and pharmaceutical use thereof 有权1,2,3,4-四氢 - 嘧啶并（1,2-a）嘧啶-6-酮衍生物及其药物用途公开(公告)号：US08846670B2
公开(公告)日：2014-09-30
申请号：US13381790
申请日：2010-07-01
Applicant: Eric Bacque , Maurice Brollo , Annie Clauss , Youssef El Ahmad , Bruno Filoche-Romme , Frank Halley , Karl Andreas Karlsson , Gilbert Marciniak , Baptiste Ronan , Laurent Schio , Bertrand Vivet , Fabrice Viviani , Andre Zimmermann
Inventor： Eric Bacque , Maurice Brollo , Annie Clauss , Youssef El Ahmad , Bruno Filoche-Romme , Frank Halley , Karl Andreas Karlsson , Gilbert Marciniak , Baptiste Ronan , Laurent Schio , Bertrand Vivet , Fabrice Viviani , Andre Zimmermann
IPC: A61K31/5377 , A61K31/519 , C07D413/14 , C07D487/04 , C07D239/06 , C07D239/42
CPC classification number: C07D487/04 , A61K31/519 , A61K31/5377 , C07D239/06 , C07D239/42 , C07D413/14
Abstract: The invention relates to compounds of the formula: or their racemic, enantiomeric or diastereoisomeric isomers, or pharmaceutically acceptable salts of the compounds of formula I or the racemic, enantiomeric or diasteroisomeric isomers.
Abstract translation: 本发明涉及下式的化合物或其外消旋，对映异构体或非对映异构体异构体或式I化合物的药学上可接受的盐或外消旋，对映异构体或非对映体异构体。
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2.发明授权2,3-dihydro-1H-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof 有权2,3-二氢-1H-咪唑并（1,2-a）嘧啶-5-酮衍生物及其药物用途公开(公告)号：US08828997B2
公开(公告)日：2014-09-09
申请号：US13381571
申请日：2010-07-01
Applicant: Maurice Brollo , Annie Clauss , Youssef El Ahmad , Bruno Filoche-Romme , Frank Halley , Karl Andreas Karlsson , Gilbert Marciniak , Baptiste Ronan , Laurent Schio , Bertrand Vivet , Fabrice Viviani , Andre Zimmermann
Inventor： Maurice Brollo , Annie Clauss , Youssef El Ahmad , Bruno Filoche-Romme , Frank Halley , Karl Andreas Karlsson , Gilbert Marciniak , Baptiste Ronan , Laurent Schio , Bertrand Vivet , Fabrice Viviani , Andre Zimmermann
IPC: A61K31/5377 , A61K31/519 , C07D413/14 , C07D487/04
CPC classification number: C07D487/04 , A61K31/519 , A61K31/5377 , C07D413/14 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415
Abstract: The invention relates to a product of formula (I) where R1, R2, R3, and R4 are as defined herein, the therapeutic use of the product, a process to make the product, and a pharmaceutical composition comprising the product.
Abstract translation: 本发明涉及式（I）的产物，其中R 1，R 2，R 3和R 4如本文所定义，产物的治疗用途，制备该产品的方法以及包含该产品的药物组合物。
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3.发明授权Imidazolone derivatives, preparation thereof as drugs, pharmaceutical compositions, and use thereof as protein kinase inhibitors, in particular CDC7 有权咪唑啉酮衍生物，作为药物的制备，药物组合物及其作为蛋白激酶抑制剂的用途，特别是CDC7公开(公告)号：US08314121B2
公开(公告)日：2012-11-20
申请号：US12415391
申请日：2009-03-31
Applicant: Vincent Leroy , Eric Bacque , Emmanuel Conseiller , Anke Steinmetz , Baptiste Ronan , Jean-Philippe Letallec
Inventor： Vincent Leroy , Eric Bacque , Emmanuel Conseiller , Anke Steinmetz , Baptiste Ronan , Jean-Philippe Letallec
IPC: A01N43/42 , A01N43/00 , A61K31/44 , A61K31/00 , A61K31/535 , C07C241/00 , C07C243/00
CPC classification number: C07D471/04
Abstract: The present invention relates to imidazolone derivatives of formula (I) to methods of preparing such derivatives, intermediates thereto, pharmaceutical compositions comprising such derivatives, and methods of inhibiting protein kinase, and methods of treatment comprising administration of such derivatives.
Abstract translation: 本发明涉及式（I）的咪唑啉酮衍生物与制备此类衍生物的方法，其中间体，包含该衍生物的药物组合物，以及抑制蛋白激酶的方法，以及包括施用此类衍生物的治疗方法。
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4.发明授权Substituted pyrazolopyridines, compositions containing them, method for the production thereof, and their use 有权取代的吡唑并吡啶，含有它们的组合物，其制备方法及其用途公开(公告)号：US08008322B2
公开(公告)日：2011-08-30
申请号：US11778870
申请日：2007-07-17
Applicant: Baptiste Ronan , Michel Tabart , Frank Halley , Eric Bacque , Catherine Souaille , Antonio Ugolini , Fabrice Viviani
Inventor： Baptiste Ronan , Michel Tabart , Frank Halley , Eric Bacque , Catherine Souaille , Antonio Ugolini , Fabrice Viviani
IPC: A61K31/437 , A61P35/00
CPC classification number: C07D471/04
Abstract: The disclosure relates to substituted pyrazolo-pyridines, compositions containing them, methods for the production thereof, and to their use as medicaments, in particular, as anticancer agents.
Abstract translation: 本公开涉及取代的吡唑并吡啶，含有它们的组合物，其制备方法及其作为药物的用途，特别是作为抗癌剂。
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5.发明授权Substituted pyrroles, compositions containing same, method for making same and use thereof 失效取代的吡咯，含有它们的组合物，其制备方法和用途公开(公告)号：US07592365B2
公开(公告)日：2009-09-22
申请号：US11832208
申请日：2007-08-01
Applicant: Baptiste Ronan , Michel Tabart , Catherine Souaille , Fabrice Viviani , Eric Bacque , Jean-Philippe Letallec , Pascal Desmazeau
Inventor： Baptiste Ronan , Michel Tabart , Catherine Souaille , Fabrice Viviani , Eric Bacque , Jean-Philippe Letallec , Pascal Desmazeau
IPC: A61K31/4025 , A61K31/166 , C12N9/99 , C07C233/57 , C07D207/34
CPC classification number: C07D207/34
Abstract: The disclosure concerns substituted pyrroles of formula (I): wherein A, L, Ar, R1, R2, R5, and Ra are as defined in the disclosure, compositions containing the same, methods for making the same and uses thereof, in particular as anti-cancer agents.
Abstract translation: 本公开涉及式（I）的取代吡咯：其中A，L，Ar，R 1，R 2，R 5和R a如本公开所定义，含有该取代吡咯的组合物，其制备方法及其用途，特别是 抗癌剂。
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Patent Agency Ranking
6.发明授权Substituted pyrroles and imidazoles, compositions containing same, manufacturing process therefor and use thereof 失效取代的吡咯和咪唑，含有它们的组合物，其制备方法和用途公开(公告)号：US07560571B2
公开(公告)日：2009-07-14
申请号：US11832206
申请日：2007-08-01
Applicant: Baptiste Ronan , Frank Halley , Catherine Souaille , Fabrice Viviani , Youssef El-Ahmad , Eric Bacque , Michel Tabart
Inventor： Baptiste Ronan , Frank Halley , Catherine Souaille , Fabrice Viviani , Youssef El-Ahmad , Eric Bacque , Michel Tabart
IPC: C07D233/64 , C07D207/30 , C07D207/46
CPC classification number: C07D207/34 , C07D233/90
Abstract: The disclosure concerns substituted imidazoles and pyrroles, compositions containing the same, the preparation thereof, and the use thereof as medicaments, particularly as anti-cancer agents.
Abstract translation: 本公开涉及取代的咪唑和吡咯，含有它们的组合物，其制备方法及其作为药物的用途，特别是作为抗癌剂。
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7.发明申请METHODS FOR THE TREATMENT OF METABOLIC AND GLUCOSE UTILIZATION DISORDERS THROUGH THE ADMINISTRATION OF OXADIAZOLONES AND DERIVATIVES THEREOF AS PEROXISOME PROLIFERATOR - ACTIVATED RECEPTOR (PPAR) DELTA AGONISTS 审中-公开用于治疗代谢性和葡萄糖利用疾病的方法通过将过氧化物酶体增殖物 - 激活受体（PPAR）三角体激动剂作为过氧化物体和衍生物的施用公开(公告)号：US20080262052A1
公开(公告)日：2008-10-23
申请号：US12133408
申请日：2008-06-05
Applicant: Stefanie KEIL , Wolfgang Wendler , Maike Glien , Jochen Goerlitzer , Karen Chandross , Daniel G. McGarry , Jean Merrill , Patrick Bernardelli , Baptiste Ronan , Corinne Terrier
Inventor： Stefanie KEIL , Wolfgang Wendler , Maike Glien , Jochen Goerlitzer , Karen Chandross , Daniel G. McGarry , Jean Merrill , Patrick Bernardelli , Baptiste Ronan , Corinne Terrier
IPC: A61K31/4245 , C07D271/06 , A61P3/10 , A61P25/28
CPC classification number: C07D417/12 , C07D413/12
Abstract: The invention relates to oxadiazolones and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta agonist activity.What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved; neurodegenerative diseases and/or de-myelinating disorders of the central and peripheral nervous systems and/or neurological diseases involving neuro-inflammatory processes and/or other peripheral neuropathies.
Abstract translation: 本发明涉及恶二唑酮及其生理上可接受的盐和生理功能衍生物，显示出PPARδ激动剂活性。 所描述的是式I化合物，其中自由基如所定义，以及它们的生理上可接受的盐及其制备方法。 该化合物适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病; 神经变性疾病和/或中枢和周围神经系统的脱髓鞘疾病和/或涉及神经炎症过程和/或其它周围神经病变的神经疾病。
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![Substituted Thieno[2,3-c]pyrazoles, Process for Preparing Them, Compositions Containing Them, and Use Thereof](/abs-image/US/2008/03/06/US20080058402A1/abs.jpg.150x150.jpg)
8.发明申请Substituted Thieno[2,3-c]pyrazoles, Process for Preparing Them, Compositions Containing Them, and Use Thereof 失效取代噻吩并[2,3-c]吡唑，其制备方法，含有它们的组合物及其用途公开(公告)号：US20080058402A1
公开(公告)日：2008-03-06
申请号：US11752612
申请日：2007-05-23
Applicant: Jean-Christophe CARRY , Gilles DOERFLINGER , Antony BIGOT , Dominique BARBALAT-DAMOUR , Francois CLERC , Arielle GENEVOIS-BORELLA , Baptiste RONAN , Herve MINOUX , Claude BARBERIS , Yves JANIN
Inventor： Jean-Christophe CARRY , Gilles DOERFLINGER , Antony BIGOT , Dominique BARBALAT-DAMOUR , Francois CLERC , Arielle GENEVOIS-BORELLA , Baptiste RONAN , Herve MINOUX , Claude BARBERIS , Yves JANIN
IPC: A61K31/4162 , A61P35/00 , C07D487/04 , C12N9/99
CPC classification number: C07D495/04
Abstract: Compounds of formula (I), wherein R1 and R3 have the meanings given in the description, said compounds being in all isomeric forms; and salts thereof; processes for the preparation of the compounds and intermediates; compositions containing them, and the use thereof as medicaments, particularly as anti-cancer agents.
Abstract translation: 式（I）化合物，其中R1和R3具有本说明书中给出的含义，所述化合物为所有异构体形式; 及其盐; 制备化合物和中间体的方法; 含有它们的组合物及其作为药物的用途，特别是作为抗癌剂。
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9.发明申请Substituted Indoles, Compositions Containing Them, Method for the Production Thereof and Their Use 失效取代的吲哚，含有它们的组合物，其生产方法及其用途公开(公告)号：US20070259910A1
公开(公告)日：2007-11-08
申请号：US11757613
申请日：2007-06-04
Applicant: Frank HALLEY , Catherine SOUAILLE , Michel TABART , Eric BACQUE , Fabrice VIVIANI , Baptiste RONAN , Jean-Philippe LETALLEC , Bruno FILOCHE-ROMME
Inventor： Frank HALLEY , Catherine SOUAILLE , Michel TABART , Eric BACQUE , Fabrice VIVIANI , Baptiste RONAN , Jean-Philippe LETALLEC , Bruno FILOCHE-ROMME
IPC: A61K31/4745 , A61K31/405 , C07D471/02 , C07D209/42
CPC classification number: C07D401/04 , C07D209/42 , C07D401/12 , C07D403/12 , C07D413/12 , C07D471/04
Abstract: Compounds of formula (I): wherein R1, R5, R6, R7, Ar, L, A, and Q are as defined in the description, and to salts thereof, to compositions containing them, to the process for preparing them, and to their use as medicinal products, in particular as anticancer agents.
Abstract translation: 式（I）化合物：其中R 1，R 5，R 6，R 7，Ar，L，A和Q如说明书中所定义，及其盐，含有它们的组合物，其制备方法，以及 其用作药用产品，特别是作为抗癌剂。
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10.发明授权Streptogramin derivatives, their preparation and compositions containing them 有权链球菌素衍生物，它们的制备和含有它们的组合物公开(公告)号：US07166594B2
公开(公告)日：2007-01-23
申请号：US10310773
申请日：2002-12-06
Applicant: Daniel Achard , Eric Bacque , Jean-Claude Barriere , Jean Bouquerel , Pascal Desmazeau , Serge Grisoni , Jean-Pierre Leconte , Yves Ribeill , Baptiste Ronan
Inventor： Daniel Achard , Eric Bacque , Jean-Claude Barriere , Jean Bouquerel , Pascal Desmazeau , Serge Grisoni , Jean-Pierre Leconte , Yves Ribeill , Baptiste Ronan
IPC: A61K31/535 , A61K31/655 , A61K31/42
CPC classification number: A61K38/12 , A61K38/15 , C07K5/06182 , A61K38/08 , A61K2300/00
Abstract: Group A streptogramin derivatives of general formula (I) in which: R1 represents a halogen atom or an azido or thiocyanato radical, R2 represents a hydrogen atom or a methyl or ethyl radical, R3 represents a hydrogen atom, or the residue of an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclylaliphatic ester which may be substituted, and the bond --- represents a single bond (stereochemistry 27R) or a double bond, as well as its salts when they exist
Abstract translation: A组通式（I）的链霉素衍生物，其中：R 1表示卤素原子或叠氮基或硫氰酸根基团，R 2表示氢原子或甲基或 乙基，R 3表示氢原子，或可以被取代的脂族，脂环族，芳族，芳脂族，杂环或杂环脂族酯的残基，并且键 ---表示单键（立体化学27R）或双键，以及其存在时的盐
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