发明授权
US07592419B2 Macrocyclic inhibitors of hepatitis C virus NS3-serine protease
失效
丙型肝炎病毒NS3-丝氨酸蛋白酶的大环抑制剂
- 专利标题： Macrocyclic inhibitors of hepatitis C virus NS3-serine protease
- 专利标题（中）： 丙型肝炎病毒NS3-丝氨酸蛋白酶的大环抑制剂
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申请号： US10948367申请日： 2004-09-23
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公开(公告)号： US07592419B2公开(公告)日： 2009-09-22
- 发明人: Srikanth Venkatraman , F. George Njoroge , Wanli Wu , Viyyoor M. Girijavallabhan , Brian McKittrick , Jing Su , Francisco Velazquez , Patrick A. Pinto
- 申请人： Srikanth Venkatraman , F. George Njoroge , Wanli Wu , Viyyoor M. Girijavallabhan , Brian McKittrick , Jing Su , Francisco Velazquez , Patrick A. Pinto
- 申请人地址： US NJ Kenilworth
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： US NJ Kenilworth
- 代理商 Palaiyur S. Kalyanaraman; Serena Farquharson-Torres
- 主分类号： A61K38/12
- IPC分类号： A61K38/12 ; A61K38/00
摘要：
The present invention discloses novel compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease. The novel compounds typically include a 15-20 member macrocycle and have the general structure of structural Formula 1: wherein Z′, L′, M′, R1, X and D are defined herein.