Invention Grant
- Patent Title: Exo- and diastereo- selective syntheses of himbacine analogs
- Patent Title (中): 烟草类似物的外切和非对映选择性合成
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Application No.: US11331324Application Date: 2006-01-12
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Publication No.: US07605275B2Publication Date: 2009-10-20
- Inventor: Frank Xing Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , George Wu , Anantha R. Sudhakar , Tao Wang , Ji Xie , Jing Liao , Ilia A. Zavialov , Hoa N. Nguyen , Ngiap Kie Lim , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam
- Applicant: Frank Xing Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , George Wu , Anantha R. Sudhakar , Tao Wang , Ji Xie , Jing Liao , Ilia A. Zavialov , Hoa N. Nguyen , Ngiap Kie Lim , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam
- Applicant Address: US NJ Kenilworth
- Assignee: Schering Corporation
- Current Assignee: Schering Corporation
- Current Assignee Address: US NJ Kenilworth
- Agency: Patent Practitioners of Schering-Plough Corporation
- Agent H. Eric Fischer
- Main IPC: C07D307/92
- IPC: C07D307/92
Abstract:
This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:
Public/Granted literature
- US20060247450A1 Exo- and diastereo- selective syntheses of himbacine analogs Public/Granted day:2006-11-02
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