An object of the invention is to provide an electrode plate for electrochemical measurements for detecting with high sensitivity and determining a substance included in a living body. The electrode plate of the present invention has on both faces of body of the substrate, oxidation electrode and reduction electrode opened respectively at upper layer opening and lower layer opening having the same area; and further has a plurality of through-holes that penetrate through from the face of the oxidation electrode to the face of the reduction electrode, in which electrode pairs are formed which exhibit a redox cycle effect between the oxidation electrode and the reduction electrode by applying the potential which can proceed an oxidative reaction of a reductant on the oxidation electrode, and the potential which can proceed a reductive reaction of an oxidant on the reduction electrode.