发明授权
US07638297B2 Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
有权
正交赖氨酰-tRNA和氨酰-tRNA合成酶对的组合及其用途
- 专利标题： Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
- 专利标题（中）： 正交赖氨酰-tRNA和氨酰-tRNA合成酶对的组合及其用途
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申请号： US10563686申请日： 2004-07-07
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公开(公告)号： US07638297B2公开(公告)日： 2009-12-29
- 发明人: J. Christopher Anderson , Ning Wu , Stephen Santoro , Peter G. Schultz
- 申请人： J. Christopher Anderson , Ning Wu , Stephen Santoro , Peter G. Schultz
- 申请人地址： US CA La Jolla
- 专利权人： The Scripps Research Institute
- 当前专利权人： The Scripps Research Institute
- 当前专利权人地址： US CA La Jolla
- 代理机构： Quine Intellectual Property Law Group
- 代理商 Gary Baker
- 国际申请： PCT/US2004/022187 WO 20040707
- 国际公布： WO2005/019415 WO 20050303
- 主分类号： C12P21/06
- IPC分类号： C12P21/06 ; C07H21/04 ; C12N9/10
摘要：
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with homoglutamines using these orthogonal pairs.
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