发明授权
- 专利标题： Method for the detection of chromosomal aneuploidies
- 专利标题（中）： 染色体非整倍体检测方法
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申请号： US11384128申请日： 2006-03-17
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公开(公告)号： US07645576B2公开(公告)日： 2010-01-12
- 发明人: Yuk-Ming Dennis Lo , Rossa Wai Kwun Chiu , Bo Yin Tsui , Chunming Ding , Charles Cantor
- 申请人： Yuk-Ming Dennis Lo , Rossa Wai Kwun Chiu , Bo Yin Tsui , Chunming Ding , Charles Cantor
- 申请人地址： HK Shantin, N.T.
- 专利权人： The Chinese University of Hong Kong
- 当前专利权人： The Chinese University of Hong Kong
- 当前专利权人地址： HK Shantin, N.T.
- 代理机构： Townsend and Townsend and Crew LLP
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C12Q1/68
摘要：
The non-invasive detection of fetal chromosomal aneuploidies is demonstrated. Alleles of fetal RNA-SNPs present in a biological sample (e.g. maternal blood) containing fetal RNA are detected and quantified in order to determine the ratio of the alleles. This ratio is compared to a standard control consisting of euploid fetuses. Deviation of allele ratio indicates the presence of chromosomal aneuploidy.
公开/授权文献
- US20060252071A1 Method for the detection of chromosomal aneuploidies 公开/授权日：2006-11-09
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