公开(公告)号：US20180214343A1

公开(公告)日：2018-08-02

申请号：US15939666

申请日：2018-03-29

Applicant: Simon Charles Cantor

Inventor： Simon Charles Cantor

IPC: A61J1/16 ,  A61M5/00

CPC classification number: A61J1/165 ,  A61J1/03 ,  A61J2200/40 ,  A61J2200/42 ,  A61J2200/44 ,  A61J2200/50 ,  A61J2200/72 ,  A61M5/002 ,  A61M2205/3368 ,  A61M2205/3372 ,  A61M2205/3553 ,  A61M2205/3592 ,  A61M2205/36 ,  A61M2205/3606 ,  A61M2205/3633 ,  A61M2205/3673 ,  A61M2205/50 ,  A61M2205/8206 ,  F25B21/04 ,  G08B25/016 ,  G16H20/13 ,  G16H40/63

Abstract: A case includes a pocket for hermitically storing medical device(s) and medicine. The case may include a manual or motorized pump that can generate vacuum pressure within the pocket to thermally insulate the pocket from the atmosphere to minimize temperature fluctuations within the pocket. The case may also include a cooling and/or heating system to control the temperature within the pocket within a desired range to prolonging the potency and the life expectancy of the drug, such as epinephrine, stored within the pocket. The case may also be equip with a communication device that can link with user's mobile device so that in case of an emergency, the communication device can alert the mobile device, which can then notify emergency personal for assistance.

公开(公告)号：US06368813B1

公开(公告)日：2002-04-09

申请号：US09381430

申请日：2000-03-23

Applicant: Gabriel O. Reznik ,  Takeshi Sano ,  Sandor Vajda ,  Cassandra Smith ,  Charles Cantor

Inventor： Gabriel O. Reznik ,  Takeshi Sano ,  Sandor Vajda ,  Cassandra Smith ,  Charles Cantor

IPC: G01N3353

CPC classification number: C07K14/36

Abstract: Compounds and methods are described for producing streptavidin mutants with changed affinities. In particular, modifications to the sequence of the natural streptavidin gene is described to create amino acid substitutions resulting in greater affinity for biotin substitutes than for biotin.

Abstract translation: 描述了用于生产具有改变的亲和力的链霉抗生物素蛋白突变体的化合物和方法。 特别地，描述了对天然链霉亲和素基因的序列的修饰以产生氨基酸取代，导致对生物素替代物的亲和力高于生物素。

公开(公告)号：USD771762S1

公开(公告)日：2016-11-15

申请号：US29539242

申请日：2015-09-11

Applicant: Jeffrey Charles Cantor

Designer： Jeffrey Charles Cantor

公开(公告)号：US20070207466A1

公开(公告)日：2007-09-06

申请号：US11364294

申请日：2006-02-28

Applicant: Charles Cantor ,  Chunming Ding ,  Yuk Lo ,  Rossa Chiu

Inventor： Charles Cantor ,  Chunming Ding ,  Yuk Lo ,  Rossa Chiu

IPC: C12Q1/68

CPC classification number: C12Q1/6881 ,  C12Q1/6872 ,  C12Q2600/156 ,  C12Q2600/172 ,  C12Q2535/125

Abstract: The present invention is directed to methods of detecting nucleic acids in a biological sample. The method is based on a novel combination of a base extension reaction, which provides excellent analytical specificity, and a mass spectrometric analysis, which provides excellent specificity. The method can be used, for example, for diagnostic, prognostic and treatment purposes. The method allows accurate detection of nucleic acids that are present in very small amounts in a biological sample. For example, the method of the present invention is preferably used to detect fetal nucleic acid in a maternal blood sample; circulating tumor-specific nucleic acids in a blood, urine or stool sample; and donor-specific nucleic acids in transplant recipients. In another embodiment, one can detect viral, bacterial, fungal, or other foreign nucleic acids in a biological sample.

Abstract translation: 本发明涉及检测生物样品中核酸的方法。 该方法基于提供优异分析特异性的碱基延伸反应和提供优异特异性的质谱分析的新型组合。 该方法可用于例如诊断，预后和治疗目的。 该方法允许精确检测在生物样品中以非常少的量存在的核酸。 例如，本发明的方法优选用于检测母体血液样品中的胎儿核酸; 在血液，尿液或粪便样品中循环肿瘤特异性核酸; 和供体特异性核酸。 在另一个实施方案中，可以检测生物样品中的病毒，细菌，真菌或其它外来核酸。

公开(公告)号：US20110172111A1

公开(公告)日：2011-07-14

申请号：US12852336

申请日：2010-08-06

Applicant: Charles Cantor ,  Hubert Köster

Inventor： Charles Cantor ,  Hubert Köster

IPC: C40B30/04

CPC classification number: C12Q1/6872 ,  C12Q1/6874 ,  C12Q2565/501 ,  C12Q2531/113 ,  C12Q2521/525 ,  C12Q2565/627 ,  C12Q2531/119 ,  C12Q2523/301 ,  C12Q2531/137 ,  C12Q2521/301 ,  C12Q2531/149

Abstract: This invention relates to methods for detecting and sequencing target nucleic acid sequences, to mass modified nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids or nucleic acids which represent complementary or homologous sequences of the target to an array of nucleic acid probes. These probes comprise a single-stranded portion, an optional double-stranded portion and a variable sequence within the single-stranded portion. The molecular weights of the hybridized nucleic acids of the set can be determined by mass spectroscopy, and the sequence of the target determined from the molecular weights of the fragments. Nucleic acids whose sequences can be determined include DNA or RNA in biological samples such as patient biopsies and environmental samples. Probes may be fixed to a solid support such as a hybridization chip to facilitate automated molecular weight analysis and identification of the target sequence.

Abstract translation: 本发明涉及用于检测和测序靶核酸序列，批量修饰的核酸探针和可用于这些方法的探针阵列的方法，以及含有这些探针的试剂盒和系统。 有用的方法包括将代表靶的互补或同源序列的核酸或核酸与核酸探针阵列进行杂交。 这些探针包括在单链部分内的单链部分，任选的双链部分和可变序列。 该组的杂交核酸的分子量可以通过质谱法测定，并且靶标的序列由片段的分子量确定。 可以确定其序列的核酸包括生物样品中的DNA或RNA，例如患者活组织检查和环境样品。 探针可以固定在固体支持物例如杂交芯片上以促进自动化分子量分析和靶序列的鉴定。

公开(公告)号：US20100047179A1

公开(公告)日：2010-02-25

申请号：US12447368

申请日：2007-10-26

Applicant: Vadim Demidov ,  Natalia Broude ,  Charles Cantor ,  William Evans

Inventor： Vadim Demidov ,  Natalia Broude ,  Charles Cantor ,  William Evans

IPC: A61K48/00 ,  C07K2/00 ,  A61K38/02 ,  A61K39/00 ,  A61K39/02 ,  A61K38/54 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61K9/127 ,  A61K9/14 ,  A61K31/7088 ,  A61K49/00

CPC classification number: A61K49/0056 ,  A61K47/56 ,  A61K47/642 ,  A61K47/6817 ,  A61K47/6819 ,  A61K47/6821 ,  A61K47/6823 ,  A61K47/6825 ,  A61K47/6827 ,  A61K47/6829 ,  A61K49/0045

Abstract: The present invention is directed to compositions and methods for the production of split-biomolecular conjugates for the directed targeting of nucleic acids and polypeptides. More preferably, the compositions and methods allow for the use of the split biomolecular conjugates for the treatment of diseases, malignancies, disorders and screening. In some embodiments, the split biomolecular conjugates comprise split effector protein fragments conjugated to a probe, and interaction of both probes with a target nucleic acid or target polypeptide, such as a pathogenic nucleic acid sequence or pathogenic protein, brings a the split-effector fragments together to facilitate the reassembly of the effector molecule. Depending on the effector molecule, the protein complementation results in a cellular effect, in particular for the treatment of diseases, malignancies and disorders.

Abstract translation: 本发明涉及用于产生用于核酸和多肽的定向靶向的分裂生物分子缀合物的组合物和方法。 更优选地，组合物和方法允许使用分裂的生物分子缀合物来治疗疾病，恶性肿瘤，病症和筛选。 在一些实施方案中，分裂的生物分子缀合物包含与探针缀合的分裂效应子蛋白片段，以及两种探针与靶核酸或靶多肽（例如致病性核酸序列或致病性蛋白质）的相互作用带来分裂效应物片段 一起以促进效应分子的重组。 取决于效应分子，蛋白质互补导致细胞效应，特别是用于治疗疾病，恶性肿瘤和病症。

公开(公告)号：US20070122805A1

公开(公告)日：2007-05-31

申请号：US10542043

申请日：2004-01-16

Applicant: Charles Cantor ,  Chunming Ding

Inventor： Charles Cantor ,  Chunming Ding

IPC: C12Q1/68 ,  C12P19/34

CPC classification number: C12Q1/6827 ,  C12Q1/6858 ,  C12Q2600/156 ,  C12Q2527/137 ,  C12Q2537/143 ,  C12Q2565/627

Abstract: The present invention provides an efficient way for high throughput haplotype analysis. Several polymorphic nucleic add markers, such as SNPs, can be simultaneously and reliably determined through multiplex PCR of single nucleic acid molecules in several parallel single molecule dilutions and the consequent statistical analysis of the results from these parallel single molecule multiplex PCR reactions results in reliable determination of haplotypes present in the subject. The nucleic acid markers can be of any distance to each other on the chromosome. In addition, an approach wherein overlapping DNA markers are analyzed can be used to link smaller haplotypes into larger haplotypes. Consequently, the invention provides a powerful new tool for diagnostic haplotyping and identifying novel haplotypes.

Abstract translation: 本发明提供了高通量单倍型分析的有效方法。 可以通过多个平行的单分子稀释物中的单个核酸分子的多重PCR同时且可靠地测定几种多态性核酸添加标记，例如SNP，并且随后对这些平行单分子多重PCR反应的结果的统计分析导致可靠的测定 的单倍体存在于受试者。 核酸标记在染色体上可以彼此有任何距离。 此外，分析重叠的DNA标记物的方法可用于将较小的单倍型连接到较大的单元型中。 因此，本发明为诊断单倍型和鉴定新型单体型提供了强大的新工具。

公开(公告)号：US20060252071A1

公开(公告)日：2006-11-09

申请号：US11384128

申请日：2006-03-17

Applicant: Yuk-Ming Lo ,  Rossa Chiu ,  Bo Tsui ,  Chunming Ding ,  Charles Cantor

Inventor： Yuk-Ming Lo ,  Rossa Chiu ,  Bo Tsui ,  Chunming Ding ,  Charles Cantor

IPC: C12Q1/68

CPC classification number: C12Q1/6881 ,  C12Q1/6851 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2545/101

Abstract: The non-invasive detection of fetal chromosomal aneuploidies is demonstrated. Alleles of fetal RNA-SNPs present in a biological sample (e.g. maternal blood) containing fetal RNA are detected and quantified in order to determine the ratio of the alleles. This ratio is compared to a standard control consisting of euploid fetuses. Deviation of allele ratio indicates the presence of chromosomal aneuploidy.

Abstract translation: 证明了胎儿染色体非整倍体的非侵入性检测。 检测并定量存在于含有胎儿RNA的生物样品（例如母体血液）中的胎儿RNA-SNP的等位基因，以确定等位基因的比例。 将该比率与由整倍体胎儿组成的标准对照进行比较。 等位基因比率的偏差表明存在染色体非整倍体。

公开(公告)号：US20060094014A1

公开(公告)日：2006-05-04

申请号：US10529122

申请日：2003-10-09

Applicant: Charles Cantor ,  Natalia Broude ,  Carlos Witte-Hoffmann

Inventor： Charles Cantor ,  Natalia Broude ,  Carlos Witte-Hoffmann

IPC: C12Q1/68 ,  C07H21/00 ,  A61K49/00

CPC classification number: C12Q1/6818 ,  C12Q1/6813 ,  C12Q2563/131 ,  C12Q2561/107

Abstract: The present invention is directed to novel methods for in vitro and in vivo detection of target nucleic acid molecules, including DNA and RNA targets, as well as nucleic acid analogues. The present invention is based on protein complementation, in which two individual polypeptides are inactive. When the two inactive polypeptide fragment are brought in close proximity during hybridization to a target nucleic acid, they re-associate into an active, detectable protein.

Abstract translation: 本发明涉及用于靶核酸分子（包括DNA和RNA靶标）以及核酸类似物的体外和体内检测的新方法。 本发明基于蛋白质互补，其中两个单独的多肽是无活性的。 当两个无活性多肽片段在与靶核酸杂交期间紧密接近时，它们重新连接成活性的可检测蛋白质。

公开(公告)号：US20050014158A1

公开(公告)日：2005-01-20

申请号：US10607806

申请日：2003-06-27

Applicant: Gail Adam ,  Maria Langdown ,  Mikhail Denissenko ,  Edward Dennis ,  Charles Cantor ,  Byron Rubin

Inventor： Gail Adam ,  Maria Langdown ,  Mikhail Denissenko ,  Edward Dennis ,  Charles Cantor ,  Byron Rubin

IPC: A61B20060101 ,  A61K31/7088 ,  A61K38/46 ,  A61K45/00 ,  A61K48/00 ,  C12Q1/00 ,  C12Q1/34 ,  C12Q1/44 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/564 ,  G01N33/566 ,  G01N33/68 ,  G01N33/92

CPC classification number: G01N33/566 ,  G01N33/564 ,  G01N33/6893 ,  G01N2500/20 ,  G01N2800/042

Abstract: Provided herein are methods for prognosing and diagnosing fat deposition and related disorders (e.g., obesity and non-insulin diabetes dependent mellitus (NIDDM)) in a subject, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for reducing fat deposition and related disorders, and therapeutic methods for reducing fat deposition or treating fat deposition related disorders in a subject. These embodiments are based in part upon an analysis of polymorphic variations of the nucleic acid set forth in SEQ ID NO:1.

Abstract translation: 本文提供了用于预测和诊断受试者的脂肪沉积和相关疾病（例如，肥胖和非胰岛素糖尿病依赖性细胞（NIDDM））的方法，用于实施该方法的试剂和试剂盒，用于鉴定用于减少脂肪沉积的候选治疗剂的方法 和相关疾病，以及用于减少受试者中脂肪沉积或治疗脂肪沉积相关疾病的治疗方法。 这些实施方案部分地基于对SEQ ID NO：1所示的核酸的多态变异的分析。