发明授权
- 专利标题： Methods for producing optically active alcohols
- 专利标题（中）： 光学活性醇的制造方法
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申请号： US11151764申请日： 2005-06-13
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公开(公告)号： US07645599B2公开(公告)日： 2010-01-12
- 发明人: Hiroaki Yamamoto , Momoko Ueda , Ritsuzui Pan , Takeshi Hamatani
- 申请人： Hiroaki Yamamoto , Momoko Ueda , Ritsuzui Pan , Takeshi Hamatani
- 申请人地址： JP Osaka
- 专利权人： Daicel Chemical Industries, Ltd.
- 当前专利权人： Daicel Chemical Industries, Ltd.
- 当前专利权人地址： JP Osaka
- 代理机构： Lahive & Cockfield, LLP
- 代理商 Jeanne M. DiGiorgi, Esq.; Maneesh Gulati, Esq.
- 优先权： JP2001-375041 20011207; JP2002-152955 20020527
- 主分类号： C12N7/02
- IPC分类号： C12N7/02 ; C12N9/04 ; C12Q1/00 ; C12Q1/68 ; C12N1/20 ; C12N15/00 ; C07H21/04 ; C12Q21/04 ; C12Q1/32
摘要：
A method for producing optically active alcohols is provided. Optically active alcohols are useful intermediates in pharmaceutical production. The method of the present invention enables simple and efficient production of optically active alcohols with a high optical purity. According to the production method disclosed, optically active alcohols are produced via asymmetric reduction of 3-quinuclidinone using tropinone reductase-I. For example, the use of tropinone reductase-I derived from plants like Datura stramonium and Hyoscyamus niger allows the production of high optical purity (R)-3-quinuclidinol.
公开/授权文献
- US20050227336A1 Methods for producing optically active alcohols 公开/授权日：2005-10-13
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